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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"GUANOSINE-5'-TRIPHOSPHATE" AND author_name:"Urlaub H" AND citation_journal_name:"CELL"

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EMD-11569

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Human C Complex Spliceosome - High-resolution CORE

Release date: Oct. 14, 2020
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6zym
Q-score: 0.498

Bertram K, El Ayoubi L, Dybkov O, Agafonov DE, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Luhrmann R

Mol Cell (2020) 80 pp. 127-139.e6 [ Pubmed: 33007253 DOI: doi:10.1016/j.molcel.2020.09.012 ]

Sample:

Pre-mrna (103 kDa, RNA from Human)
Inositol hexakisphosphate (660 Da, Ligand)
U2 snrna (60 kDa, RNA from Human)
Protein frg1 (29 kDa, Protein from Human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Human)
Splicing factor yju2 (21 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Pre-mrna-splicing factor cwc25 homolog (49 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
U5 snrna (36 kDa, RNA from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Corepressor interacting with rbpj 1 (52 kDa, Protein from Human)
Pre-mrna-processing-splicing factor 8 (207 kDa, Protein from Human)
Wd repeat-containing protein 70 (73 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Pre-mrna-splicing factor atp-dependent rna helicase prp16 (140 kDa, Protein from Human)
Human c complex spliceosome - high resolution core (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
U6 snrna (25 kDa, RNA from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (107 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
Pre-mrna-splicing factor rbm22 (25 kDa, Protein from Human)

[Show more]

EMD-4255

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human Bact spliceosome core structure

Release date: Aug. 29, 2018
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6ff4
Q-score: 0.443

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H

Cell (2018) 172 pp. 454-464.e11 [ Pubmed: 29361316 DOI: doi:10.1016/j.cell.2018.01.010 ]

Sample:

Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Human)
Splicing factor 3b subunit 1 (146 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Splicing factor 3b subunit 6 (14 kDa, Protein from Human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Splicing factor 3a subunit 2 (49 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
Ring finger protein 113a (38 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
U6 snrna (34 kDa, RNA from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Human)
U2 snrna (60 kDa, RNA from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Human)
Splicing factor 3b subunit 5 (10 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Splicing factor 3b subunit 2 (100 kDa, Protein from Human)
Pre mrna (153 kDa, RNA from Homo sapiens)
Zinc ion (65 Da, Ligand)
Human bact spliceosome state 1 unmasked (4 MDa, Complex from Homo sapiens)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
U5 snrna (36 kDa, RNA from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
Splicing factor 3b subunit 3 (135 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Human)
Bud13 homolog (70 kDa, Protein from Human)

[Show more]

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EMDB [2]

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