GDNF/GFRa1 cell adhesion complex cryo-ET structure
Houghton FM, Adams SE, Rios AS, Masino L, Purkiss AG, Briggs DC, Ledda F, McDonald NQ
Nat Commun (2023) 14 pp. 7551-7551 [ Pubmed: 37985758 DOI: doi:10.1038/s41467-023-43148-8 ]
GDNF/GFRa1 cell adhesion complex bridging between adhering liposomes.
Houghton FM, Adams SE, Rios AS, Masino L, Purkiss AG, Briggs DC, Ledda F, McDonald NQ
Nat Commun (2023) 14 pp. 7551-7551 [ DOI: doi:10.1038/s41467-023-43148-8 Pubmed: 37985758 ]
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7aml
Q-score: 0.33
Adams SE, Purkiss AG, Knowles PP, Nans A, Briggs DC, Borg A, Earl CP, Goodman KM, Nawrotek A, Borg AJ, McIntosh PB, Houghton FM, Kjaer S, McDonald NQ
Structure (2021) 29 pp. 694- [ DOI: doi:10.1016/j.str.2020.12.012 Pubmed: 33484636 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glial cell line-derived neurotrophic factor (11 kDa, Protein from Danio rerio)
- Ternary complex of ret extracellular domain with gdnf and gfra1 ligand-coreceptor pair (240 kDa, Complex from Danio rerio)
- Gdnf family receptor alpha (39 kDa, Protein from Danio rerio)
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6q2n
Q-score: 0.223
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Glial cell line-derived neurotrophic factor (15 kDa, Protein from Homo sapiens)
- Gdnf family receptor alpha-1 (46 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Structure of the RET receptor tyrosine kinase extracellular domain
Resolution: 24.0 Å
EM Method: Single-particle
Fitted PDBs: 4ux8
Q-score: 0.062
Goodman K, Kjaer S, Beuron F, Knowles P, Nawrotek A, Burns E, Purkiss A, George R, Santoro M, Morris EP, McDonald NQ
Cell Rep (2014) 8 pp. 1894-1904 [ DOI: doi:10.1016/j.celrep.2014.08.040 Pubmed: 25242331 ]
- Ret receptor tyrosine kinase (80 kDa, Protein from Homo sapiens)
- Reconstituted mammalian retecd-gdnf-gfra1 ternary complex (340 kDa, Sample)
- Gdnf receptor alpha (40 kDa, Protein from Rattus norvegicus)
- Glial-cell-line-derived neurotrophic factor (10 kDa, Protein from Homo sapiens)
Structure of the zebrafish RET tyrosine kinase extracellular domain
Goodman K, Kjaer S, Beuron F, Knowles P, Nawrotek A, Burns E, Purkiss A, George R, Santoro M, Morris EP, McDonald NQ
Cell Rep (2014) 8 pp. 1894-1904 [ DOI: doi:10.1016/j.celrep.2014.08.040 Pubmed: 25242331 ]
- Gdnf receptor alpha (Protein from Danio rerio)
- Reconstituted zebrafish retecd-gdnf-gfra1 ternary complex (240 kDa, Sample)
- Glial-cell-line-derived neurotrophic factor (Protein from Danio rerio)
- Ret receptor tyrosine kinase (83 kDa, Protein from Danio rerio)