To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Hexadecane (226 Da, Ligand)
Human neutral shpingomyelinase
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8j2f
Q-score: 0.539
Yi J, Qi B, Yin J, Li R, Chen X, Hu J, Li G, Zhang S, Zhang Y, Yang M
Nat Commun (2023) 14 pp. 7755-7755 [ DOI: doi:10.1038/s41467-023-43580-w Pubmed: 38012235 ]
- Human neutral sphingomyelinases (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Heptane (100 Da, Ligand)
- Sphingomyelin phosphodiesterase 2 (47 kDa, Protein from Homo sapiens)
- Tetradecane (198 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8dn2
Q-score: 0.417
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexane (86 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state 2(expanded-open state) (240 kDa, Complex from Homo sapiens)
- Undecane (156 Da, Ligand)
- N-octane (114 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- N-butane (58 Da, Ligand)
- Glycine (75 Da, Ligand)
- Nonane (128 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8dn3
Q-score: 0.482
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Heptane (100 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- Undecane (156 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Nonane (128 Da, Ligand)
- N-butane (58 Da, Ligand)
- Decane (142 Da, Ligand)
- Heteromeric glycine receptor alpha-1 and beta, apo state (240 kDa, Complex from Homo sapiens)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8dn5
Q-score: 0.462
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexane (86 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Undecane (156 Da, Ligand)
- N-butane (58 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Glycine (75 Da, Ligand)
- Nonane (128 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state1 (open state) (240 kDa, Complex from Homo sapiens)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
structure of a membrane-integrated glycosyltransferase with inhibitor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xs6
Q-score: 0.572
Wu YN, Zhang M, Yang YZ, Ding XY, Liu XT, Zhang MJ, Yu HJ
To Be Published
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- Membrane-integrated glycosyltransferase (Complex from Saccharomyces cerevisiae)
- (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) (495 Da, Ligand)
- (19r,22s)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9z)-hexadec-9-enoate (689 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
structure of a membrane-integrated glycosyltransferase
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xs7
Q-score: 0.547
Wu YN, Zhang M, Yang YZ, Ding XY, Liu XT, Zhang MJ, Yu HJ
To Be Published
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- Membrane-integrated glycosyltransferase (Complex from Saccharomyces cerevisiae)
- (19r,22s)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9z)-hexadec-9-enoate (689 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
structure of a membrane-bound glycosyltransferase
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xe4
Q-score: 0.471
Hu X, Yang P, Chai C, Liu J, Sun H, Wu Y, Zhang M, Zhang M, Liu X, Yu H
Nature (2023) 616 pp. 190-198 [ Pubmed: 36949198 DOI: doi:10.1038/s41586-023-05856-5 ]
- 1,3-beta-glucan synthase component fks1 (215 kDa, Protein from baker's yeast)
- Heptane (100 Da, Ligand)
- Dodecane (170 Da, Ligand)
- (11r,14s)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate (495 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Membrane-bound glycosyltransferase (215 kDa, Complex from Saccharomyces cerevisiae)
- Nonane (128 Da, Ligand)
- Decane (142 Da, Ligand)
Structure of a mutated membrane-bound glycosyltransferase
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7yuy
Q-score: 0.494
Hu X, Yang P, Chai C, Liu J, Sun H, Wu Y, Zhang M, Zhang M, Liu X, Yu H
Nature (2023) 616 pp. 190-198 [ Pubmed: 36949198 DOI: doi:10.1038/s41586-023-05856-5 ]
- Membrane-bound glycosyltransferase (215 kDa, Complex from Saccharomyces cerevisiae)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- 1,3-beta-glucan synthase component fks1 (215 kDa, Protein from Saccharomyces cerevisiae)
- Nonane (128 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- (11r,14s)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate (495 Da, Ligand)
apo SERT reconstituted in lipid nanodisc in KCl
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7li6
Q-score: 0.436
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ DOI: doi:10.1126/sciadv.abl3857 Pubmed: 34851672 ]
- Pentane (72 Da, Ligand)
- Apo state of human serotonin transporter in complex with 15b8 fab in kcl (Complex from Homo sapiens)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from mouse)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from mouse)
- Hexadecane (226 Da, Ligand)