Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8qmo
Q-score: 0.573
Kwong HS, Paloni M, Grandvuillemin L, Sirounian S, Ancelin A, Lai-Kee-Him J, Grimaldi M, Carivenc C, Lancey C, Ragan TJ, Hesketh EL, Balaguer P, Barducci A, Gruszczyk J, Bourguet W
J Mol Biol (2024) 436 pp. 168411-168411 [ DOI: doi:10.1016/j.jmb.2023.168411 Pubmed: 38135181 ]
- Aryl hydrocarbon receptor (49 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Benzo[a]pyrene (252 Da, Ligand)
- Heat shock protein hsp 90-beta (84 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ah receptor-interacting protein (37 kDa, Protein from Homo sapiens)
- Benzo[a]pyrene-bound hsp90-xap2-ahr complex (254 kDa, Complex from Homo sapiens)
- Molybdate ion (159 Da, Ligand)
GC-C-Hsp90-Cdc37 regulatory complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8fx4
Q-score: 0.329
Caveney NA, Tsutsumi N, Garcia KC
eLife (2023) 12 [ Pubmed: 37535399 DOI: doi:10.7554/eLife.86784 ]
- Guanylyl cyclase c (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Gc-c-hsp90-cdc37 regulatory complex (Complex)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Cricetulus griseus)
- Hsp90 co-chaperone cdc37 (44 kDa, Protein from Cricetulus griseus)
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ Pubmed: 37069154 DOI: doi:10.1038/s41467-023-37659-7 ]
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Hsp90:cdc37:craf complex (57 kDa, Complex from Homo sapiens)
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
Hsp90 provides platform for CRaf dephosphorylation by PP5
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8gft
Q-score: 0.333
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ Pubmed: 37069154 DOI: doi:10.1038/s41467-023-37659-7 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Hsp90:cdc37:craf:pp5 complex (57 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90 co-chaperone cdc37, n-terminally processed (45 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Serine/threonine-protein phosphatase 5 (57 kDa, Protein from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (34 kDa, Protein from Homo sapiens)
Hsp90 provides platform for CRaf dephosphorylation by PP5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gae
Q-score: 0.326
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ Pubmed: 37069154 DOI: doi:10.1038/s41467-023-37659-7 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Hsp90:cdc37:craf:pp5 complex (57 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Hsp90 co-chaperone cdc37 (45 kDa, Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Raf proto-oncogene serine/threonine-protein kinase (23 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Serine/threonine-protein phosphatase 5 (57 kDa, Protein from Homo sapiens)
PP5 TPR domain bound to Hsp90:Cdc37:CRaf complex
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5 tpr domain. (57 kDa, Complex from Homo sapiens)
PP5 bound to Hsp90:Cdc37:CRaf complex
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5. (57 kDa, Complex from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
PP5 bound to Hsp90:Cdc37:CRaf complex (conformation II)
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5. (57 kDa, Complex from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8eoa
Q-score: 0.343
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ Pubmed: 36657440 DOI: doi:10.1016/j.str.2022.12.014 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
- Aryl-hydrocarbon-interacting protein-like 1 (40 kDa, Protein from Mus musculus)
- Hsp90b/aipl1 complex (215 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eob
Q-score: 0.516
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ Pubmed: 36657440 DOI: doi:10.1016/j.str.2022.12.014 ]
- Magnesium ion (24 Da, Ligand)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Hsp90b dimer in the closed amppnp bound state (174 kDa, Complex from Homo sapiens)