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Tissue biology and disease modelling

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Structural biology

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Structural biology

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Epigenetics and neurobiology

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sample_name:"IRON/SULFUR CLUSTER" AND author_name:"Skehel M" AND xref_links:"interpro" AND structure_determination_method:"singleparticle" AND assembly_molecular_weight:{500000 TO 1000000]

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EMD-4482

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Isolated complex I class refinement from Ovine respiratory supercomplex I+III2

Release date: Aug. 21, 2019
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6qa9
Q-score: 0.337

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
Cardiolipin (1 kDa, Ligand)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (14 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Ndufs8 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Sheep)
Ndufv3 (8 kDa, Protein from Ovis aries)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Ovine mitochondrial complex i (1 MDa, Complex from Ovis aries)
Ndufc1 (5 kDa, Protein from Ovis aries)
Ndufs7 (20 kDa, Protein from Ovis aries)
Ndufs2 (49 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Sheep)
Ndufa13 (16 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from Sheep)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Ndufs6 (10 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)

[Show more]

EMD-4497

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Ovine respiratory complex I FRC closed class 1

Release date: Aug. 21, 2019
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6qc5
Q-score: 0.351

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Ndufb11 (14 kDa, Protein from Sheep)
Ndufv2 (23 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Ndufs8 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Sheep)
Ndufa5 (13 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s7,ndufs7 (20 kDa, Protein from Ovis aries)
Flavin mononucleotide (456 Da, Ligand)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Ndufv3 (8 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Ndufc1 (5 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Sheep)
Ndufa7 (12 kDa, Protein from Sheep)
Ndufa11 (14 kDa, Protein from Sheep)
Ndufa13 (16 kDa, Protein from Ovis aries)
Ndufb6 (15 kDa, Protein from Sheep)
Ndufs2,nadh:ubiquinone oxidoreductase core subunit s2 (49 kDa, Protein from Sheep)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Ndufs6 (10 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Ndufb1 (6 kDa, Protein from Sheep)

[Show more]

EMD-4498

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Ovine respiratory complex I FRC open class 1

Release date: Aug. 21, 2019
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6qc6
Q-score: 0.362

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (49 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
Cardiolipin (1 kDa, Ligand)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (14 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b10 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a7 (12 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Sheep)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from Sheep)
Nadh dehydrogenase 1 alpha subcomplex (8 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s7 (20 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit v3 (8 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from Sheep)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)

[Show more]

EMD-4499

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Ovine respiratory complex I FRC open class 3

Release date: Aug. 21, 2019
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6qc7
Q-score: 0.335

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Ndufb11 (14 kDa, Protein from Sheep)
Ndufv2 (23 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
Cardiolipin (1 kDa, Ligand)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Ndufs8 (20 kDa, Protein from Ovis aries)
Ndufb1 (6 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Sheep)
Ndufa5 (13 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Sheep)
Ndufv3 (8 kDa, Protein from Ovis aries)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Ndufc1 (5 kDa, Protein from Ovis aries)
Ndufs7 (20 kDa, Protein from Ovis aries)
Ndufs2 (49 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Sheep)
Ndufa7 (12 kDa, Protein from Sheep)
Ndufa11 (14 kDa, Protein from Sheep)
Ndufa13 (16 kDa, Protein from Ovis aries)
Ndufb6 (15 kDa, Protein from Sheep)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Ndufs6 (10 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)

[Show more]

EMD-4500

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Ovine respiratory complex I FRC open class 2

Release date: Aug. 21, 2019
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6qc8
Q-score: 0.366

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Ndufv2 (23 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
Cardiolipin (1 kDa, Ligand)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (14 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Sheep)
Ndufa5 (13 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b10 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from Sheep)
Nadh dehydrogenase 1 alpha subcomplex (8 kDa, Protein from Sheep)
Nadh dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kda (6 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s7 (20 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Sheep)
Ndufa7 (12 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit v3 (8 kDa, Protein from Sheep)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from Sheep)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s2 (49 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)

[Show more]

EMD-4501

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Ovine respiratory complex I FRC open class 4

Release date: Aug. 21, 2019
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 6qc9
Q-score: 0.265

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Ovis aries)
Ndufc1 (5 kDa, Protein from Ovis aries)
Acyl carrier protein (10 kDa, Protein from Ovis aries)
Ndufa5 (13 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Ovis aries)
Ndufv3 (8 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Ovis aries)
Ndufa11 (14 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Ovis aries)
Ndufs2 (49 kDa, Protein from Ovis aries)
Ndufa7 (12 kDa, Protein from Ovis aries)
Ndufv2 (23 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Ovis aries)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Ovis aries)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Ovis aries)
Iron/sulfur cluster (351 Da, Ligand)
Ndufa13 (16 kDa, Protein from Ovis aries)
Ndufb1 (6 kDa, Protein from Ovis aries)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Zinc ion (65 Da, Ligand)
Ndufb11 (14 kDa, Protein from Ovis aries)
Ndufb6 (15 kDa, Protein from Ovis aries)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Ndufs6 (10 kDa, Protein from Ovis aries)
Ndufs8 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Ovis aries)
Ndufs7 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Ovis aries)

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EMD-4502

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Ovine respiratory complex I FRC open class 5

Release date: Aug. 21, 2019
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 6qca
Q-score: 0.248

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Ovis aries)
Ndufc1 (5 kDa, Protein from Ovis aries)
Acyl carrier protein (10 kDa, Protein from Ovis aries)
Ndufa5 (13 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Ovis aries)
Ndufv3 (8 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Ovis aries)
Ndufa11 (14 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Ovis aries)
Ndufs2 (49 kDa, Protein from Ovis aries)
Ndufa7 (12 kDa, Protein from Ovis aries)
Ndufv2 (23 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Ovis aries)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Ovis aries)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Ovis aries)
Iron/sulfur cluster (351 Da, Ligand)
Ndufa13 (16 kDa, Protein from Ovis aries)
Ndufb1 (6 kDa, Protein from Ovis aries)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Zinc ion (65 Da, Ligand)
Ndufb11 (14 kDa, Protein from Ovis aries)
Ndufb6 (15 kDa, Protein from Ovis aries)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Ndufs6 (10 kDa, Protein from Ovis aries)
Ndufs8 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Ovis aries)
Ndufs7 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Ovis aries)

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EMD-4505

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Ovine respiratory complex I FRC open class 6

Release date: Aug. 21, 2019
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6qcf
Q-score: 0.244

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Ovis aries)
Ndufs8 (20 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Ovis aries)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b2 (8 kDa, Protein from Ovis aries)
Ndufb10 (20 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b5 (16 kDa, Protein from Ovis aries)
Ovine mitochondrial respiratory complex i (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from Ovis aries)
Ndufv3 (8 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Ovis aries)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Ovis aries)
Ndufc1 (5 kDa, Protein from Ovis aries)
Ndufs2 (49 kDa, Protein from Ovis aries)
Ndufs7 (20 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from Ovis aries)
Ndufa1 (8 kDa, Protein from Ovis aries)
Acyl carrier protein (10 kDa, Protein from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Ovis aries)
Iron/sulfur cluster (351 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (14 kDa, Protein from Ovis aries)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Ovis aries)
Ndufs6 (10 kDa, Protein from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from Ovis aries)
Ndufb1 (6 kDa, Protein from Ovis aries)
Flavin mononucleotide (456 Da, Ligand)
Ndufa13 (16 kDa, Protein from Ovis aries)

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