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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"IRON/SULFUR CLUSTER" AND author_name:"Skehel M" AND xref_links:"uniprot" AND resolution:[3 TO 4} AND xref_links:"interpro"

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EMD-4480

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CI Peripheral Arm focused refinement from Ovine respiratory SC I+III2

Release date: Aug. 21, 2019
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6q9d
Q-score: 0.424

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA

Mol Cell (2019) 75 pp. 1131-1146.e6 [ DOI: doi:10.1016/j.molcel.2019.07.022 Pubmed: 31492636 ]

Sample:

Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (10 kDa, Protein from Sheep)
Ovine mitochondrial sc i+iii2 (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s4 (15 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (14 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase core subunit s3 (26 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh:ubiquinone oxidoreductase core subunit s1 (77 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s2,nadh:ubiquinone oxidoreductase core subunit s2 (49 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s8 (20 kDa, Protein from Sheep)
Acyl carrier protein (10 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Iron/sulfur cluster (351 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit v3 (8 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s7 (20 kDa, Protein from Sheep)

[Show more]

EMD-4093

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Entire ovine respiratory complex I, Combined Map

Release date: Nov. 23, 2016
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 5lnk
Q-score: 0.408

Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA

Nature (2016) 538 pp. 406-410 [ Pubmed: 27595392 DOI: doi:10.1038/nature19794 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Mitochondrial complex i, 75 kda subunit (77 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Cardiolipin (1 kDa, Ligand)
Mitochondrial complex i, tyky subunit (20 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (8 kDa, Protein from Sheep)
Mitochondrial complex i, 30 kda subunit (26 kDa, Protein from Sheep)
Mitochondrial complex i, 24 kda subunit (23 kDa, Protein from Sheep)
Mitochondrial complex i, nd1 subunit (35 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Mitochondrial complex i, 15 kda subunit (12 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, b12 subunit (11 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (10 kDa, Protein from Sheep)
Mitochondrial complex i (970 kDa, Complex from Ovis aries)
Mitochondrial complex i, 42 kda subunit (36 kDa, Protein from Sheep)
Mitochondrial complex i, b9 subunit (9 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Mitochondrial complex i, psst subunit (20 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Mitochondrial complex i, esss subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, nd6 subunit (19 kDa, Protein from Sheep)
Mitochondrial complex i, b14 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, b15 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, nd4 subunit (52 kDa, Protein from Sheep)
Mitochondrial complex i, nd3 subunit (13 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5b subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (10 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
Mitochondrial complex i, 49 kda subunit (47 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Mitochondrial complex i, b8 subunit (10 kDa, Protein from Sheep)
Mitochondrial complex i, b22 subunit (21 kDa, Protein from Sheep)
Mitochondrial complex i, pgiv subunit (20 kDa, Protein from Sheep)
Mitochondrial complex i, nd5 subunit (67 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
4'-phosphopantetheine (358 Da, Ligand)
Mitochondrial complex i, mnll subunit (6 kDa, Protein from Sheep)
Mitochondrial complex i, 18 kda subunit (15 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Mitochondrial complex i, nd4l subunit (10 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (10 kDa, Protein from Sheep)
Mitochondrial complex i, nd2 subunit (39 kDa, Protein from Sheep)
Mitochondrial complex i, kfyi subunit (5 kDa, Protein from Sheep)
Mitochondrial complex i, 51 kda subunit (48 kDa, Protein from Sheep)
Mitochondrial complex i, b17.2 subunit (17 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
Mitochondrial complex i, 39 kda subunit (38 kDa, Protein from Sheep)
Mitochondrial complex i, b18 subunit (16 kDa, Protein from Sheep)
Mitochondrial complex i, sgdh subunit (16 kDa, Protein from Sheep)
Mitochondrial complex i, aggg subunit (8 kDa, Protein from Sheep)

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