Cryo-EM structure of human Elp123 in complex with tRNA, acetyl-CoA, 5'-deoxyadenosine and methionine
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8ptx
Q-score: 0.441
Abbassi NE, Jaciuk M, Scherf D, Bohnert P, Rau A, Hammermeister A, Rawski M, Indyka P, Wazny G, Chramiec-Glabik A, Dobosz D, Skupien-Rabian B, Jankowska U, Rappsilber J, Schaffrath R, Lin TY, Glatt S
Nat Commun (2024) 15 pp. 4094-4094 [ DOI: doi:10.1038/s41467-024-48251-y Pubmed: 38750017 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Human elp123 in complex with glutamine trna, acetyl-coa, 5'-deoxyadenosine and methionine (635 kDa, Complex from Homo sapiens)
- Trna gln (24 kDa, RNA from Homo sapiens)
- Elongator complex protein 1 (150 kDa, Protein from Homo sapiens)
- Elongator complex protein 2 (92 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- 5'-deoxyadenosine (251 Da, Ligand)
- Elongator complex protein 3 (65 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of human Elp123 in complex with 5'-deoxyadenosine and methionine
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8pty
Q-score: 0.487
Abbassi NE, Jaciuk M, Scherf D, Bohnert P, Rau A, Hammermeister A, Rawski M, Indyka P, Wazny G, Chramiec-Glabik A, Dobosz D, Skupien-Rabian B, Jankowska U, Rappsilber J, Schaffrath R, Lin TY, Glatt S
Nat Commun (2024) 15 pp. 4094-4094 [ DOI: doi:10.1038/s41467-024-48251-y Pubmed: 38750017 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Human elp123 in complex with 5'-deoxyadenosine and methionine (610 kDa, Complex from Homo sapiens)
- Elongator complex protein 3 (65 kDa, Protein from Homo sapiens)
- Elongator complex protein 1 (150 kDa, Protein from Homo sapiens)
- Elongator complex protein 2 (92 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- 5'-deoxyadenosine (251 Da, Ligand)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8ptz
Q-score: 0.386
Abbassi NE, Jaciuk M, Scherf D, Bohnert P, Rau A, Hammermeister A, Rawski M, Indyka P, Wazny G, Chramiec-Glabik A, Dobosz D, Skupien-Rabian B, Jankowska U, Rappsilber J, Schaffrath R, Lin TY, Glatt S
Nat Commun (2024) 15 pp. 4094-4094 [ DOI: doi:10.1038/s41467-024-48251-y Pubmed: 38750017 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Trna gln (24 kDa, RNA from Homo sapiens)
- Elongator complex protein 2 (92 kDa, Protein from Homo sapiens)
- Elongator complex protein 1 (150 kDa, Protein from Homo sapiens)
- 5'-deoxyadenosine (251 Da, Ligand)
- Elongator complex protein 3 (65 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Human elp123 in complex with glutamine trna, s-ethyl-coa, 5'-deoxyadenosine and methionine (635 kDa, Complex from Homo sapiens)
- S-ethyl-coa (795 Da, Ligand)
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8pu0
Q-score: 0.277
Abbassi NE, Jaciuk M, Scherf D, Bohnert P, Rau A, Hammermeister A, Rawski M, Indyka P, Wazny G, Chramiec-Glabik A, Dobosz D, Skupien-Rabian B, Jankowska U, Rappsilber J, Schaffrath R, Lin TY, Glatt S
Nat Commun (2024) 15 pp. 4094-4094 [ DOI: doi:10.1038/s41467-024-48251-y Pubmed: 38750017 ]
- 5'-deoxyadenosine (251 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Human elp123 in complex with glutamine trna, desulpho-coa, 5'-deoxyadenosine and methionine (635 kDa, Complex from Homo sapiens)
- Desulfo-coenzyme a (735 Da, Ligand)
- Elongator complex protein 3 (65 kDa, Protein from Homo sapiens)
- Elongator complex protein 1 (150 kDa, Protein from Homo sapiens)
- Elongator complex protein 2 (92 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- Trna gln (24 kDa, RNA from Homo sapiens)
Cryo-EM structure of yeast Elongator complex
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 8asv
Q-score: 0.372
Jaciuk M, Scherf D, Kaszuba K, Gaik M, Rau A, Koscielniak A, Krutyholowa R, Rawski M, Indyka P, Graziadei A, Chramiec-Glabik A, Biela A, Dobosz D, Lin TY, Abbassi NE, Hammermeister A, Rappsilber J, Kosinski J, Schaffrath R, Glatt S
Nucleic Acids Res (2023) 51 pp. 2011-2032 [ DOI: doi:10.1093/nar/gkac1232 Pubmed: 36617428 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Elongator complex protein 1 (153 kDa, Protein from Saccharomyces cerevisiae)
- Elongator complex protein 4 (51 kDa, Protein from Saccharomyces cerevisiae)
- Elongator complex protein 6 (30 kDa, Protein from Saccharomyces cerevisiae)
- Elongator complex protein 5 (35 kDa, Protein from Saccharomyces cerevisiae)
- Elongator complex protein 3 (63 kDa, Protein from Saccharomyces cerevisiae)
- Yeast elongator complex (845 kDa, Complex from Saccharomyces cerevisiae)
- Elongator complex protein 2 (89 kDa, Protein from Saccharomyces cerevisiae)