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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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EMD-31204

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TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)

Release date: May 26, 2021
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7ena
Q-score: 0.168

Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y

Science (2021) 372 [ Pubmed: 33958484 DOI: doi:10.1126/science.abg0635 ]

Sample:

Dna-directed rna polymerase (Complex)
Dna-directed rna polymerase ii subunit rpb4 (16 kDa, Protein from Pig)
Cdk-activating kinase assembly factor mat1 (35 kDa, Protein from Homo sapiens)
General transcription factor iie subunit 1 (49 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 19 (26 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 4 (110 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit f (14 kDa, Protein from Pig)
Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Pig)
Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
Dna (Complex)
Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
Tfiid-based pic-mediator holo-complex in pre-assembled state (pre-hpic-med) (Complex from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
General transcription and dna repair factor iih helicase subunit xpd (87 kDa, Protein from Homo sapiens)
Rna_pol_l_2 domain-containing protein (13 kDa, Protein from Pig)
Transcription initiation factor iie subunit beta (33 kDa, Protein from Homo sapiens)
Iron/sulfur cluster (351 Da, Ligand)
Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
Tfiih (Complex from Homo sapiens)
Cyclin-h (37 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Pig)
Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 1 (212 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
Dna(69-mer) (21 kDa, DNA from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Pig)
Tfiid (Complex from Sus scrofa)
Transcription initiation factor tfiid subunit 6 (72 kDa, Protein from Homo sapiens)
Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
Isoform 2 of mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 12 (17 kDa, Protein from Homo sapiens)
Dna (69-mer) (21 kDa, DNA from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 2 (44 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
Tfiib (Complex from Homo sapiens)
Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 10 (21 kDa, Protein from Homo sapiens)
Mediator (Complex from Homo sapiens)
Dna-directed rna polymerase ii subunit e (24 kDa, Protein from Pig)
Tfiif (Complex from Homo sapiens)
Transcription initiation factor tfiid subunit 13 (14 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 8 (34 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
Tfiie (Complex from Homo sapiens)
Isoform 2 of mediator of rna polymerase ii transcription subunit 16 (93 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 5 (86 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Transcription initiation factor tfiid subunit 3 (103 kDa, Protein from Homo sapiens)
General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
Rpb1 (217 kDa, Protein from Pig)
Transcription initiation factor tfiid subunit 9 (29 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
Tfiia (Complex from Homo sapiens)
Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 11 (23 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 26 (65 kDa, Protein from Homo sapiens)
Rpb12 (7 kDa, Protein from Pig)
General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 2 (137 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from Pig)
Rpb10 (7 kDa, Protein from Sus scrofa)
Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Tfiia-a (34 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 7 (40 kDa, Protein from Homo sapiens)
General transcription and dna repair factor iih helicase subunit xpb (89 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase subunit beta (134 kDa, Protein from Pig)
General transcription factor iih subunit 4 (52 kDa, Protein from Homo sapiens)

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EMD-31112

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p53-bound TFIID-based holo PIC on HDM2 promoter

Release date: May 12, 2021
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7egc
Q-score: 0.051

Chen X, Qi Y, Wu Z, Wang X, Li J, Zhao D, Hou H, Li Y, Yu Z, Liu W, Wang M, Ren Y, Li Z, Yang H, Xu Y

Science (2021) 372 [ DOI: doi:10.1126/science.aba8490 Pubmed: 33795473 ]

Sample:

Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Pig)
Rna polymerase ii (Complex from Sus scrofa)
Dna (71-mer) (21 kDa, DNA from Homo sapiens)
Transcription initiation factor tfiid subunit 10 (21 kDa, Protein from Homo sapiens)
Rpb12 (7 kDa, Protein from Pig)
Rna_pol_l_2 domain-containing protein (13 kDa, Protein from Pig)
General transcription factor iie subunit 1 (49 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 3 (103 kDa, Protein from Homo sapiens)
P53-bound tfiid-based holo pic on hdm2 promoter (Complex)
Transcription initiation factor tfiid subunit 12 (17 kDa, Protein from Homo sapiens)
Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Pig)
Dna-directed rna polymerase ii subunit rpb1 (217 kDa, Protein from Human)
General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 7 (40 kDa, Protein from Homo sapiens)
Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
Transcription initiation factor iie subunit beta (33 kDa, Protein from Homo sapiens)
Cyclin-h (37 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 2 (137 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Pig)
Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from Pig)
Cdk-activating kinase assembly factor mat1 (35 kDa, Protein from Homo sapiens)
Rpb10 (7 kDa, Protein from Pig)
Tfiih (Complex)
Transcription initiation factor tfiid subunit 5 (86 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 6 (72 kDa, Protein from Homo sapiens)
Iron/sulfur cluster (351 Da, Ligand)
General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
General transcription and dna repair factor iih helicase subunit xpb (89 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 8 (34 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 4 (52 kDa, Protein from Homo sapiens)
Dna (71-mer) (22 kDa, DNA from Homo sapiens)
Tfiib (Complex from Homo sapiens)
Transcription initiation factor tfiid subunit 13 (14 kDa, Protein from Homo sapiens)
General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Dna-directed rna polymerase ii subunit f (14 kDa, Protein from Pig)
Dna(hdm2 promoters) (Complex)
Transcription initiation factor tfiid subunit 1 (212 kDa, Protein from Homo sapiens)
General transcription and dna repair factor iih helicase subunit xpd (87 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 11 (23 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit e (24 kDa, Protein from Pig)
General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb4 (16 kDa, Protein from Pig)
General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
Tfiid (Complex from Homo sapiens)
Transcription initiation factor tfiid subunit 4 (110 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 9 (29 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase subunit beta (134 kDa, Protein from Pig)
Tfiif (Complex from Homo sapiens)
General transcription factor iih subunit 2 (44 kDa, Protein from Homo sapiens)
Tfiia (Complex from Homo sapiens)

[Show more]

EMD-31111

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TFIID-based holo PIC on SCP promoter

Release date: May 5, 2021
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7egb
Q-score: 0.012

Chen X, Qi Y, Wu Z, Wang X, Li J, Zhao D, Hou H, Li Y, Yu Z, Liu W, Wang M, Ren Y, Li Z, Yang H, Xu Y

Science (2021) 372 [ DOI: doi:10.1126/science.aba8490 Pubmed: 33795473 ]

Sample:

Transcription initiation factor tfiid subunit 11 (23 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 13 (14 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from pig)
Rpb10 (7 kDa, Protein from Pig)
Dna-directed rna polymerase subunit beta (134 kDa, Protein from pig)
Rna polymerase ii (Complex from Sus scrofa)
Dna-directed rna polymerase ii subunit rpb1 (217 kDa, Protein from human)
Dna (69-mer) (21 kDa, DNA from Homo sapiens)
Transcription initiation factor tfiid subunit 6 (72 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 8 (34 kDa, Protein from Homo sapiens)
Cdk-activating kinase assembly factor mat1 (35 kDa, Protein from Homo sapiens)
Tfiid (Complex from Homo sapiens)
General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
General transcription factor iie subunit 1 (49 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 4 (110 kDa, Protein from Homo sapiens)
General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 2 (137 kDa, Protein from Homo sapiens)
Dna (69-mer) (29 kDa, DNA from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from pig)
Transcription initiation factor tfiid subunit 12 (17 kDa, Protein from Homo sapiens)
Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit rpb4 (16 kDa, Protein from pig)
General transcription factor iih subunit 2 (44 kDa, Protein from Homo sapiens)
Dna(scp promoters) (Complex)
Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from pig)
Zinc ion (65 Da, Ligand)
General transcription and dna repair factor iih helicase subunit xpd (87 kDa, Protein from Homo sapiens)
Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
Tfiib (Complex from Homo sapiens)
Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 10 (21 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 5 (86 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Transcription initiation factor iie subunit beta (33 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 3 (103 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 7 (40 kDa, Protein from Homo sapiens)
Tfiih (Complex)
General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
Iron/sulfur cluster (351 Da, Ligand)
Rna_pol_l_2 domain-containing protein (13 kDa, Protein from pig)
General transcription and dna repair factor iih helicase subunit xpb (89 kDa, Protein from Homo sapiens)
Tfiid-based holo pic on scp promoter (Complex)
Cyclin-h (37 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 9 (29 kDa, Protein from Homo sapiens)
Rpb12 (7 kDa, Protein from pig)
General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit e (24 kDa, Protein from pig)
Tfiia (Complex from Homo sapiens)
Tfiif (Complex from Homo sapiens)
Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase ii subunit f (14 kDa, Protein from pig)
Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from pig)
General transcription factor iih subunit 4 (52 kDa, Protein from Homo sapiens)
Transcription initiation factor tfiid subunit 1 (212 kDa, Protein from Homo sapiens)

[Show more]

EMD-30577

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cryo-EM structure of human RNA polymerase III in elongating state

Release date: Feb. 17, 2021
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7d58
Q-score: 0.014

Wang Q, Li S, Wan F, Xu Y, Wu Z, Cao M, Lan P, Lei M, Wu J

Nat Struct Mol Biol (2021) 28 pp. 220-227 [ Pubmed: 33558766 DOI: doi:10.1038/s41594-021-00557-x ]

Sample:

Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
Non-template dna (12 kDa, DNA from Homo sapiens)
Human pol3 ec (Complex from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
Template dna (12 kDa, DNA from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
Rna (6 kDa, RNA from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
Iron/sulfur cluster (351 Da, Ligand)
Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)

[Show more]

EMD-30578

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cryo-EM structure of human RNA polymerase III in apo state

Release date: Feb. 17, 2021
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7d59
Q-score: 0.391

Wang Q, Li S, Wan F, Xu Y, Wu Z, Cao M, Lan P, Lei M, Wu J

Nat Struct Mol Biol (2021) 28 pp. 220-227 [ DOI: doi:10.1038/s41594-021-00557-x Pubmed: 33558766 ]

Sample:

Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
Rna pol3 apo (Complex from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
Iron/sulfur cluster (351 Da, Ligand)
Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)

[Show more]

Sort by: Download

Showing 1 - 5 of 5. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [5]

Format:

Select the script type:

Shell (Unix-based) Batch (Windows-based)

Preview first 10

Field: