CryoEM structure of MFRV-VILP bound to IGF1Rzip
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8tan
Q-score: 0.424
Chrudinova M, Kirk NS, Chuard A, Venugopal H, Zhang F, Lubos M, Gelfanov V, Panikova T, Zakova L, Cutone J, Mojares M, DiMarchi R, Jiracek J, Altindis E
Mol Metab (2024) 80 pp. 101863-101863 [ DOI: doi:10.1016/j.molmet.2023.101863 Pubmed: 38182007 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1:2 complex of mfrv-vilp bound to igf1rzip (Complex)
- Mfrv-vilp (Complex from Mandarin fish ranavirus)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Igf1rzip (Complex from Homo sapiens)
- Insulin-like growth factor (6 kDa, Protein from Mandarin fish ranavirus)
Cryo-EM structure of IGF1R with two IGF1 complex
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7yrr
Q-score: 0.175
To Be Published
- Isoform 3 of insulin-like growth factor i (6 kDa, Protein from Homo sapiens)
- Insulin-like growth factor 1 receptor (102 kDa, Protein from Homo sapiens)
- Deterotetramer complex of igf1r with igf1 (Complex from Homo sapiens)
Cryo-EM structure of Apo-IGF1R map 1
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7xgd
Q-score: 0.201
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor 1 receptor (102 kDa, Protein from Homo sapiens)
- Apo-igf1r (Complex from Homo sapiens)
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u23
Q-score: 0.188
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinova M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
Nat Commun (2022) 13 pp. 6700-6700 [ Pubmed: 36335114 DOI: doi:10.1038/s41467-022-34391-6 ]
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8eyr
Q-score: 0.346
Li J, Wu J, Hall C, Bai XC, Choi E
eLife (2022) 11 [ DOI: doi:10.7554/eLife.81286 Pubmed: 36413010 ]
- Two igf1 bound full-length mouse igf1r mutant (four glycine residues inserted in the alpha-ct; igf1r-p674g4): symmetric conformation (Complex from Mus musculus)
- Insulin-like growth factor 1 receptor (144 kDa, Protein from Mus musculus)
- Insulin-like growth factor i (21 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7s0q
Q-score: 0.328
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Beta-d-mannopyranose (180 Da, Ligand)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7s8v
Q-score: 0.232
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwg
Q-score: 0.453
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ Pubmed: 32459985 DOI: doi:10.1016/j.str.2020.05.002 ]
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (Complex)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vwi
Q-score: 0.407
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ Pubmed: 32459985 DOI: doi:10.1016/j.str.2020.05.002 ]
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (Complex)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Head region of the close-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the full-length human IGF-1R in complex with insulin
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 6jk8
Q-score: 0.122
Zhang X, Yu D, Sun J, Wu Y, Gong J, Li X, Liu L, Liu S, Liu J, Wu Y, Li D, Ma Y, Han X, Zhu Y, Wu Z, Wang Y, Ouyang Q, Wang T
Structure (2020) 28 pp. 555-561.e4 [ DOI: doi:10.1016/j.str.2020.03.007 Pubmed: 32275863 ]
- Insulin-like growth factor 1 receptor (154 kDa, Protein from Homo sapiens)
- Insulin (11 kDa, Protein from Homo sapiens)
- Complex of full-length human type 1 insulin-like growth factor receptor with insulin (310 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)