Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)
Cryo-EM map of human IL-27 signaling complex with full extracellular domains
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human il-27 in complex with il-27r alpha and gp130 (Complex from Homo sapiens)
- Interleukin-27 subunit beta (23 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Interleukin-27 receptor subunit alpha (55 kDa, Protein from Homo sapiens)
- Interleukin-27 subunit alpha (27 kDa, Protein from Homo sapiens)
Cryo-EM map of human IL-27 signaling complex: focused refinement on the interaction core region
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8d85
Q-score: 0.336
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human il-27 in complex with il-27r alpha and gp130 (Complex from Homo sapiens)
- Interleukin-27 subunit beta (23 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Interleukin-27 receptor subunit alpha (55 kDa, Protein from Homo sapiens)
- Interleukin-27 subunit alpha (27 kDa, Protein from Homo sapiens)