Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Metabotropic glutamate receptor 5 bound to Quis and CDPPB, in complex with Nb43"

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EMD-41139

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Quis and CDPPB bound active mGlu5

Release date: Oct. 11, 2023
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tao
Q-score: 0.486

Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK

Nature (2024) 629 pp. 951-956 [ Pubmed: 38632403 DOI: doi:10.1038/s41586-024-07327-x ]

Sample:

Metabotropic glutamate receptor 5 (98 kDa, Protein from Homo sapiens)
(s)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid (189 Da, Ligand)
Metabotropic glutamate receptor 5 bound to quis and cdppb, in complex with nb43 (Cellular component from Homo sapiens)
Nb43 (13 kDa, Protein from Lama glama)
3-cyano-n-(1,3-diphenyl-1h-pyrazol-5-yl)benzamide (364 Da, Ligand)

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