Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"N-(4-fluorophenyl)-4,5-dimethyl-6-[(1R)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]pyrimidin-2-amine"

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EMD-32299

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Cryo-EM structure of the gastric proton pump complexed with revaprazan

Release date: March 2, 2022
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 7w4a
Q-score: 0.536

Tanaka S, Morita M, Yamagishi T, Madapally HV, Hayashida K, Khandelia H, Gerle C, Shigematsu H, Oshima A, Abe K

J Med Chem (2022) 65 pp. 7843-7853 [ DOI: doi:10.1021/acs.jmedchem.2c00338 Pubmed: 35604136 ]

Sample:

2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Sodium ion (22 Da, Ligand)
N-(4-fluorophenyl)-4,5-dimethyl-6-[(1r)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]pyrimidin-2-amine (362 Da, Ligand)
Water (18 Da, Ligand)
Potassium-transporting atpase alpha chain 1 (114 kDa, Protein from Sus scrofa)
Magnesium ion (24 Da, Ligand)
Potassium-transporting atpase subunit beta (33 kDa, Protein from Sus scrofa)
Gastric proton pump (135 kDa, Complex from Sus scrofa)

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