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sample_name:"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial" AND author_orcid:"0000-0002-3846-0147" AND xref_links:"pdbekb" AND electron_source:"FIELD EMISSION GUN" AND resolution:[2 TO 3} AND film_detector_model:"GATAN K3 BIOQUANTUM (6K X 4K)" AND sample_type:"protein" AND microscope_name:"FEI TITAN KRIOS" AND author_name:"Grba DN"
Release date: June 5, 2024
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8q1p
Q-score: 0.604
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8q1p
Q-score: 0.604
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ Pubmed: 38870289 DOI: doi:10.1126/science.ado2075 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Cardiolipin (1 kDa, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome and then deactivated with heat treatment. (1 MDa, Complex from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
Release date: June 5, 2024
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q1y
Q-score: 0.614
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q1y
Q-score: 0.614
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ DOI: doi:10.1126/science.ado2075 Pubmed: 38870289 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome and then deactivated with heat treatment. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Myristic acid (228 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
Release date: June 5, 2024
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8q25
Q-score: 0.597
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8q25
Q-score: 0.597
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ Pubmed: 38870289 DOI: doi:10.1126/science.ado2075 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Ubiquinone-10 (863 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome and then deactivated with heat treatment. (1 MDa, Complex from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8q45
Q-score: 0.633
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8q45
Q-score: 0.633
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ Pubmed: 38870289 DOI: doi:10.1126/science.ado2075 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Ubiquinone-10 (863 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q46
Q-score: 0.644
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q46
Q-score: 0.644
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ DOI: doi:10.1126/science.ado2075 Pubmed: 38870289 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Myristic acid (228 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8q47
Q-score: 0.601
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8q47
Q-score: 0.601
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ Pubmed: 38870289 DOI: doi:10.1126/science.ado2075 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Ubiquinone-10 (863 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8q48
Q-score: 0.637
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8q48
Q-score: 0.637
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ Pubmed: 38870289 DOI: doi:10.1126/science.ado2075 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Ubiquinone-10 (863 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q49
Q-score: 0.617
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q49
Q-score: 0.617
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ DOI: doi:10.1126/science.ado2075 Pubmed: 38870289 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- [[(2~{r},3~{s},4~{r},5~{r})-5-[(3~{r})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate (749 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Myristic acid (228 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)
Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG.
Release date: June 5, 2024
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q4a
Q-score: 0.627
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q4a
Q-score: 0.627
Grba DN, Wright JJ, Yin Z, Fisher W, Hirst J
Science (2024) 384 pp. 1247-1253 [ DOI: doi:10.1126/science.ado2075 Pubmed: 38870289 ]
Sample:
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Bos taurus)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Bos taurus)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Bos taurus)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- Cholic acid (408 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Bos taurus)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Bos taurus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Bos taurus)
- Potassium ion (39 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Bos taurus)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Bos taurus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Bos taurus)
- Ubiquinone-10 (863 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Bos taurus)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Bos taurus)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Bos taurus)
- Complex i from bos taurus reconstituted into proteoliposome. (1 MDa, Complex from Bos taurus)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Bos taurus)