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sample_name:"NADH-ubiquinone oxidoreductase chain 3" AND xref_links:"chebi" AND author_name:"Wojciechowska-bason A"

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EMD-14637

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Complex I from Ovis aries, at pH7.4, Open state

Release date: Sept. 21, 2022
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7zd6
Q-score: 0.561

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ DOI: doi:10.1038/s41586-022-05199-7 Pubmed: 36104567 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from sheep)
Complex i from ovis aries, at ph7.4, open state (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (8 kDa, Protein from sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (11 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (7 kDa, Protein from sheep)
Complex i-49kd (52 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (24 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from sheep)
Complex i-pdsw (20 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (8 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Complex i-mwfe (8 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (5 kDa, Protein from sheep)

[Show more]

EMD-14648

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Complex I from Ovis aries at pH7.4, Closed state

Release date: Sept. 21, 2022
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7zdh
Q-score: 0.513

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ Pubmed: 36104567 DOI: doi:10.1038/s41586-022-05199-7 ]

Sample:

Complex i-mwfe (8 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (11 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (5 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from sheep)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (8 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (8 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from sheep)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (49 kDa, Protein from sheep)
Complex i-23kd (24 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (14 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (24 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit a6 (13 kDa, Protein from sheep)
Complex i from ovis aries at ph7.4, closed state (1 MDa, Complex from Ovis aries)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (7 kDa, Protein from sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from sheep)

[Show more]

EMD-14651

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Complex I from Ovis aries at pH5.5, Open state

Release date: Sept. 21, 2022
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7zdj
Q-score: 0.547

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ Pubmed: 36104567 DOI: doi:10.1038/s41586-022-05199-7 ]

Sample:

Complex i-mwfe (8 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Complex i-30kd (24 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from sheep)
Complex i-mnll (6 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from sheep)
Complex i-b18 (14 kDa, Protein from sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from sheep)
Complex i-49kd (52 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from sheep)
Complex i-23kd (20 kDa, Protein from sheep)
Potassium ion (39 Da, Ligand)
Zinc ion (65 Da, Ligand)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Complex i subunit b13 (13 kDa, Protein from sheep)
Complex i-b14 (13 kDa, Protein from sheep)
Complex i-pdsw (20 kDa, Protein from sheep)
Complex i-b22 (21 kDa, Protein from sheep)
Complex i-b9 (8 kDa, Protein from sheep)
Complex i-kfyi (5 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Complex i-sgdh (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Complex i-20kd (17 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Complex i-9kd (5 kDa, Protein from sheep)
Complex i from ovis aries at ph5.5, open state (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from sheep)
Complex i-esss (11 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Flavin mononucleotide (456 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
Complex i-b14.7 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Complex i-b12 (8 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from sheep)
Complex i-aggg (7 kDa, Protein from sheep)

[Show more]

EMD-14658

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Complex I from Ovis aries at pH5.5, Closed state

Release date: Sept. 21, 2022
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 7zdm
Q-score: 0.524

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ DOI: doi:10.1038/s41586-022-05199-7 Pubmed: 36104567 ]

Sample:

Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (7 kDa, Protein from sheep)
Complex i-23kd (24 kDa, Protein from sheep)
Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from sheep)
Complex i-20kd (24 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from sheep)
Complex i from ovis aries at ph5.5, closed state (1 MDa, Complex from Ovis aries)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from sheep)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Mitochondrial complex i, esss subunit (17 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Complex i-49kd (52 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from sheep)
Complex i-9kd (11 kDa, Protein from sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from sheep)
Zinc ion (65 Da, Ligand)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Complex i-mwfe (8 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from sheep)

[Show more]

EMD-14664

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Complex I from Ovis aries at pH9, Open state

Release date: Sept. 21, 2022
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7zdp
Q-score: 0.437

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ DOI: doi:10.1038/s41586-022-05199-7 Pubmed: 36104567 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Complex i from ovis aries at ph9, open state (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from sheep)
Adenosine monophosphate (347 Da, Ligand)
Complex i-sgdh (16 kDa, Protein from sheep)
Complex i-kfyi (5 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from sheep)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Complex i-b9 (8 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Complex i-b18 (14 kDa, Protein from sheep)
Complex i-b14 (13 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
Complex i-mnll (6 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from sheep)
Complex i-49kd (52 kDa, Protein from sheep)
Complex i subunit b13 (13 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from sheep)
Complex i-pdsw (20 kDa, Protein from sheep)
Complex i-23kd (20 kDa, Protein from sheep)
Complex i-b14.7 (14 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Complex i-b12 (8 kDa, Protein from sheep)
Complex i-20kd (17 kDa, Protein from sheep)
Complex i-aggg (7 kDa, Protein from sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from sheep)
Complex i-30kd (24 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Complex i-mwfe (8 kDa, Protein from sheep)
Complex i-9kd (5 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Complex i-esss (11 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Complex i-b22 (21 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)

[Show more]

EMD-14688

Download Map 3D View

Complex I from Ovis aries at pH9, Closed state

Release date: Sept. 21, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7zeb
Q-score: 0.452

Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L

Nature (2022) 609 pp. 808-814 [ DOI: doi:10.1038/s41586-022-05199-7 Pubmed: 36104567 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Complex i-23kd (24 kDa, Protein from sheep)
Potassium ion (39 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from sheep)
Adenosine monophosphate (347 Da, Ligand)
Complex i-sgdh (16 kDa, Protein from sheep)
Complex i-kfyi (5 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from sheep)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (49 kDa, Protein from sheep)
Complex i-b9 (8 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from sheep)
Complex i-b14 (13 kDa, Protein from sheep)
Myristic acid (228 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from sheep)
Complex i-mnll (6 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from sheep)
Complex i-pdsw (20 kDa, Protein from sheep)
Complex i-b14.7 (14 kDa, Protein from sheep)
Iron/sulfur cluster (351 Da, Ligand)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Complex i-b12 (8 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from sheep)
Complex i from ovis aries at ph9, closed state (1 MDa, Complex from Ovis aries)
Complex i-aggg (7 kDa, Protein from sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from sheep)
Complex i-30kd (24 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit b4 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from sheep)
Acyl carrier protein (17 kDa, Protein from sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from sheep)
Complex i-mwfe (8 kDa, Protein from sheep)
Complex i-9kd (5 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from sheep)
Complex i-esss (11 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from sheep)
Complex i-b22 (21 kDa, Protein from sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (38 kDa, Protein from sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from sheep)

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