Drosophila melanogaster complex I in the Active state (Dm1)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8b9z
Q-score: 0.515
Agip AA, Chung I, Sanchez-Martinez A, Whitworth AJ, Hirst J
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84424 Pubmed: 36622099 ]
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (24 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (15 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (17 kDa, Protein from fruit fly)
- Ld31474p (20 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 39 kda subunit, isoform a (42 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from fruit fly)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (11 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (42 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 4l (11 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 5 (65 kDa, Protein from fruit fly)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Complex i-49kd (48 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from fruit fly)
- Rh45008p (7 kDa, Protein from fruit fly)
- Mitochondrial respiratory complex i (1 MDa, Complex from Drosophila melanogaster)
- Sodium ion (22 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 1 (36 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (17 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from fruit fly)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (11 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (18 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (18 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (6 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (12 kDa, Protein from fruit fly)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (17 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (18 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from fruit fly)
- Ubiquinone-9 (795 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (13 kDa, Protein from fruit fly)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase (ubiquinone) 24 kda subunit, isoform a (23 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (12 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 23 kda subunit (21 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (16 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (78 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from fruit fly)
- Iron/sulfur cluster (351 Da, Ligand)
- Geo11417p1 (7 kDa, Protein from fruit fly)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Acyl carrier protein, mitochondrial (9 kDa, Protein from fruit fly)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from fruit fly)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 13 kda b subunit (13 kDa, Protein from fruit fly)
Drosophila melanogaster complex I in the Twisted state (Dm2)
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8ba0
Q-score: 0.435
Agip AA, Chung I, Sanchez-Martinez A, Whitworth AJ, Hirst J
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84424 Pubmed: 36622099 ]
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from fruit fly)
- Geo11417p1 (6 kDa, Protein from fruit fly)
- Complex i-49kd (48 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (24 kDa, Protein from fruit fly)
- Ld31474p (20 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 39 kda subunit, isoform a (42 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (16 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (11 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (42 kDa, Protein from fruit fly)
- Cardiolipin (1 kDa, Ligand)
- Nadh-ubiquinone oxidoreductase chain 5 (65 kDa, Protein from fruit fly)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from fruit fly)
- Rh45008p (7 kDa, Protein from fruit fly)
- Mitochondrial respiratory complex i (1 MDa, Complex from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (48 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 1 (36 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (17 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from fruit fly)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (11 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (18 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (18 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (6 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (12 kDa, Protein from fruit fly)
- Zinc ion (65 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (18 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (13 kDa, Protein from fruit fly)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase (ubiquinone) 24 kda subunit, isoform a (23 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (15 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (12 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 23 kda subunit (21 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (16 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (78 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from fruit fly)
- Iron/sulfur cluster (351 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from fruit fly)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from fruit fly)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from fruit fly)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from fruit fly)
- Nadh-ubiquinone oxidoreductase chain 4l (11 kDa, Protein from fruit fly)
- Nadh dehydrogenase (ubiquinone) 13 kda b subunit (13 kDa, Protein from fruit fly)