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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"NEDD8" AND xref_links:"pdb" AND release_date:[2021-01-01T00:00:00Z TO 2021-12-31T23:59:59Z]

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EMD-12995

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Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2*

Release date: Sept. 15, 2021
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7oni
Q-score: 0.464

Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA

Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]

Sample:

Nedd8 (9 kDa, Protein from Homo sapiens)
Ring-box protein 2 (12 kDa, Protein from Homo sapiens)
Neddylated cul5 c-terminal region-rbx2-arih2 (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Cullin-5 (91 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase arih2 (57 kDa, Protein from Homo sapiens)

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EMD-12037

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Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1

Release date: Feb. 10, 2021
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b5l
Q-score: 0.427

Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klugel M, Scott DC, Ovaa H, Kleiger G, Schulman BA

Nature (2021) 590 pp. 671-676 [ Pubmed: 33536622 DOI: doi:10.1038/s41586-021-03197-9 ]

Sample:

Nedd8-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (Complex from Homo sapiens)
Cullin-1 (89 kDa, Protein from Homo sapiens)
S-phase kinase-associated protein 2 (47 kDa, Protein from Homo sapiens)
Nedd8 (8 kDa, Protein from Homo sapiens)
Cyclin-a2 (48 kDa, Protein from Homo sapiens)
Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase arih1 (64 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
Cyclin-dependent kinase inhibitor 1b (22 kDa, Protein from Homo sapiens)
Ubiquitin-conjugating enzyme e2 l3 (17 kDa, Protein from Homo sapiens)
5-azanylpentan-2-one (101 Da, Ligand)
Polyubiquitin-c (8 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (300 kDa, Complex)
Cyclin-dependent kinase 2 (34 kDa, Protein from Homo sapiens)
Cullin-1, e3 ubiquitin-protein ligase rbx1 (Complex from Homo sapiens)
S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)

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EMD-12041

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Focused map-catalytic side. Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1.

Release date: Feb. 10, 2021
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b5n
Q-score: 0.467

Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klugel M, Scott DC, Ovaa H, Kleiger G, Schulman BA

Nature (2021) 590 pp. 671-676 [ DOI: doi:10.1038/s41586-021-03197-9 Pubmed: 33536622 ]

Sample:

E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase arih1 (64 kDa, Protein from Homo sapiens)
Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (300 kDa, Complex)
Nedd8-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (Complex from Homo sapiens)
Ubiquitin-conjugating enzyme e2 l3 (17 kDa, Protein from Homo sapiens)
Cul1, rbx1 (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Cullin-1 (89 kDa, Protein from Homo sapiens)
Nedd8 (9 kDa, Protein from Homo sapiens)
Polyubiquitin-c (8 kDa, Protein from Homo sapiens)
5-azanylpentan-2-one (101 Da, Ligand)

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EMD-12048

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Focused map- CyclinA-CDK2-class. Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27. Transition State 1

Release date: Feb. 10, 2021
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b5r
Q-score: 0.409

Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klugel M, Scott DC, Ovaa H, Kleiger G, Schulman BA

Nature (2021) 590 pp. 671-676 [ Pubmed: 33536622 DOI: doi:10.1038/s41586-021-03197-9 ]

Sample:

Cullin-1 (89 kDa, Protein from Homo sapiens)
Cyclin-dependent kinases regulatory subunit 1 (9 kDa, Protein from Homo sapiens)
S-phase kinase-associated protein 2 (47 kDa, Protein from Homo sapiens)
Cyclin-a2 (48 kDa, Protein from Homo sapiens)
Cyclin-dependent kinase inhibitor 1b (22 kDa, Protein from Homo sapiens)
Cyclin-dependent kinase 2 (34 kDa, Protein from Homo sapiens)
Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (300 kDa, Complex from Homo sapiens)
S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)

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EMD-12050

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Focused map- Cullin scaffold. Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1

Release date: Feb. 10, 2021
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b5s
Q-score: 0.48

Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klugel M, Scott DC, Ovaa H, Kleiger G, Schulman BA

Nature (2021) 590 pp. 671-676 [ DOI: doi:10.1038/s41586-021-03197-9 Pubmed: 33536622 ]

Sample:

E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase arih1 (64 kDa, Protein from Homo sapiens)
E3 ubiquitin-protein ligase arih1 (Complex from Homo sapiens)
Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (300 kDa, Complex)
Cullin-1, e3 ubiquitin-protein ligase rbx1 (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Cullin-1 (89 kDa, Protein from Homo sapiens)

[Show more]

Sort by: Download

Showing 1 - 5 of 5. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [5]

Format:

Select the script type:

Shell (Unix-based) Batch (Windows-based)

Preview first 10

Field: