Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 8teo
Q-score: 0.632
Stix R, Tan XF, Bae C, Fernandez-Marino AI, Swartz KJ, Faraldo-Gomez JD
Sci Adv (2023) 9 pp. eadj5539-eadj5539 [ Pubmed: 38064553 DOI: doi:10.1126/sciadv.adj5539 ]
- Voltage-gated potassium channel shaker (Cell from Drosophila melanogaster)
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium voltage-gated channel protein shaker (74 kDa, Protein from Drosophila melanogaster)
CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8sda
Q-score: 0.478
Fernandez-Marino AI, Tan XF, Bae C, Huffer K, Jiang J, Swartz KJ
Nature (2023) 622 pp. 410-417 [ DOI: doi:10.1038/s41586-023-06582-8 Pubmed: 37758949 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium voltage-gated channel subfamily b member 1 (68 kDa, Protein from Rattus norvegicus)
- Potassium ion (39 Da, Ligand)
- Voltage-dependent potassium channel kv2.1 l403a mutant (Complex from Rattus norvegicus)
Structure of human Kv1.3 with Fab-ShK fusion
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 7ssv
Q-score: 0.441
Selvakumar P, Fernandez-Marino AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 pp. 3854-3854 [ DOI: doi:10.1038/s41467-022-31285-5 Pubmed: 35788586 ]
- Potassium ion (39 Da, Ligand)
- Potassium voltage-gated channel subfamily a member 3,green fluorescent protein fusion (95 kDa, Protein from Aequorea victoria)
- Kv1.3 with fab-shk (Complex from Homo sapiens)
- Fab-shk fusion, light chain (22 kDa, Protein from unidentified)
- Fab-shk fusion, heavy chain (29 kDa, Protein from unidentified)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7ssx
Q-score: 0.515
Selvakumar P, Fernandez-Marino AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 pp. 3854-3854 [ DOI: doi:10.1038/s41467-022-31285-5 Pubmed: 35788586 ]
Structure of human Kv1.3 with A0194009G09 nanobodies
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7ssz
Q-score: 0.481
Selvakumar P, Fernandez-Marino AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 pp. 3854-3854 [ DOI: doi:10.1038/s41467-022-31285-5 Pubmed: 35788586 ]
- Kv1.3 with nanobody a0194009g09 (Complex from Homo sapiens)
- Nanobody a0194009g09 (13 kDa, Protein from synthetic construct)
- Potassium voltage-gated channel subfamily a member 3,green fluorescent protein fusion (95 kDa, Protein from Aequorea victoria)
- Potassium ion (39 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7sip
Q-score: 0.529
Tan XF, Bae C, Stix R, Fernandez-Marino AI, Huffer K, Chang TH, Jiang J, Faraldo-Gomez JD, Swartz KJ
Sci Adv (2022) 8 pp. eabm7814-eabm7814 [ DOI: doi:10.1126/sciadv.abm7814 Pubmed: 35302848 ]
- Potassium channel (Cell from Drosophila melanogaster)
- Water (18 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium voltage-gated channel protein shaker (69 kDa, Protein from Drosophila melanogaster)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7sj1
Q-score: 0.49
Tan XF, Bae C, Stix R, Fernandez-Marino AI, Huffer K, Chang TH, Jiang J, Faraldo-Gomez JD, Swartz KJ
Sci Adv (2022) 8 pp. eabm7814-eabm7814 [ DOI: doi:10.1126/sciadv.abm7814 Pubmed: 35302848 ]
- Potassium voltage-gated channel protein shaker (69 kDa, Protein from Drosophila melanogaster)
- Potassium channel (Cell from Drosophila melanogaster)
- Water (18 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)