Structure of 1:1 PAPP-A.ProMBP complex(half map)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7y5n
Q-score: 0.476
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of 1:1 papp-a/prombp complex(half map) (Complex from Homo sapiens)
- Pappalysin-1 (172 kDa, Protein from human)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Bone marrow proteoglycan (25 kDa, Protein from human)
Structure of 1:1 PAPP-A.STC2 complex(half map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y5q
Q-score: 0.438
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Structure of 1:1 papp-a/stc2 complex(half map) (Complex from Homo sapiens)
- Stanniocalcin-2 (33 kDa, Protein from human)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of 2:2 PAPP-A.ProMBP complex
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8hgg
Q-score: 0.408
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Zinc ion (65 Da, Ligand)
- Pappalysin-1 (181 kDa, Protein from human)
- Bone marrow proteoglycan (25 kDa, Protein from human)
- Structure of 2:2 papp-a/prombp complex (Complex from Homo sapiens)
Structure of 2:2 PAPP-A.STC2 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8hgh
Q-score: 0.295
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Stanniocalcin-2 (33 kDa, Protein from human)
- Structure of 2:2 papp-a/stc2 complex (Complex from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Partial dimer complex of PAPP-A and its inhibitor STC2
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8a7d
Q-score: 0.457
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ Pubmed: 36257932 DOI: doi:10.1038/s41467-022-33698-8 ]
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C-terminal part of papp-a (Complex from Homo sapiens)
- Subunit of stanniocalcin-2 (Complex from Homo sapiens)
- Partial papp-a dimer in complex with subunit of its endogenous inhibitor stc2 dimer (500 kDa, Complex from Homo sapiens)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
- Papp-a (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- N-terminal part of papp-a (Complex from Homo sapiens)
PAPP-A dimer in complex with its inhibitor STC2
Resolution: 5.02 Å
EM Method: Single-particle
Fitted PDBs: 8a7e
Q-score: 0.147
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Stanniocalcin-2 (Complex from Homo sapiens)
- Pregnancy-associated plasma protein a (Complex from Homo sapiens)
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (100 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
Cryo-EM structure of PAPP-A in complex with IGFBP5
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7ufg
Q-score: 0.443
Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q
Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]
- Zinc ion (65 Da, Ligand)
- Complex of papp-a with igfbp5 (Complex from Homo sapiens)
- Pappalysin-1 (176 kDa, Protein from Homo sapiens)
- Insulin-like growth factor-binding protein 5 (30 kDa, Protein from Homo sapiens)
Cryo-EM structure of substrate unbound PAPP-A
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8d8o
Q-score: 0.44
Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q
Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]
- Papp-a homodimer (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Pappalysin-1 (176 kDa, Protein from Homo sapiens)