Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6q2j
Q-score: 0.111
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- Gdnf family receptor alpha-like (39 kDa, Protein from Homo sapiens)
- Growth/differentiation factor 15 (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6q2n
Q-score: 0.223
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Glial cell line-derived neurotrophic factor (15 kDa, Protein from Homo sapiens)
- Gdnf family receptor alpha-1 (46 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 6q2o
Q-score: 0.062
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Gdnf family receptor alpha-2 (39 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neurturin (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6q2r
Q-score: 0.134
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Gdnf family receptor alpha-2 (39 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neurturin (11 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6q2s
Q-score: 0.208
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ DOI: doi:10.7554/eLife.47650 Pubmed: 31535977 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ubiquitin-like protein smt3,artemin (25 kDa, Protein from Homo sapiens)
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
- Gdnf family receptor alpha-3 (38 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)