Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9erx
Q-score: 0.448
Gloriam D, Thorsen T, Kulkarni Y, Sykes D, Boggild A, Drace T, Hompluem P, Iliopoulos-Tsoutsouvas C, Nikas S, Daver H, Makriyannis A, Nissen P, Gajhede M, Veprintsev D, Boesen T, Kastrup J
Res Sq (2024) [ DOI: doi:10.21203/rs.3.rs-4277209/v1 Pubmed: 38826401 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody scfv16 (Complex from Mus musculus)
- Cannabinoid receptor 1 (57 kDa, Protein from Homo sapiens)
- Antibody scfv16 fab fragment (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cannabinoid 1 receptor complexed with a g protein (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (6ar,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol (386 Da, Ligand)
- Hu210/cb1/gi1 signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
Cell Discov (2024) 10 pp. 58-58 [ DOI: doi:10.1038/s41421-024-00670-3 Pubmed: 38830850 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Orexigenic neuropeptide qrfp (2 kDa, Protein from Homo sapiens)
- Pyroglutamylated rf-amide peptide receptor (49 kDa, Protein from Homo sapiens)
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Structure of 26rfa-pyroglutamylated rfamide peptide receptor-g protein complex (160 kDa, Complex from Homo sapiens)
Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
To Be Published
- Cortistatin (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Cortistatin 17-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex
To Be Published
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ikg
Q-score: 0.432
To Be Published
- Cb02-bound cb1r in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 3-[(1s)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1h-indole (332 Da, Ligand)
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ikh
Q-score: 0.431
To Be Published
- Cb05-bound cb1r in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- 3-[(1r)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1h-indole (372 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
- Gi heterotrimer (Complex from Homo sapiens)
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of the histamine-bound H3R-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yuu
Q-score: 0.566
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) pp. e2310120-e2310120 [ Pubmed: 38647423 DOI: doi:10.1002/advs.202310120 ]
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of the immepip-bound H3R-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8yuv
Q-score: 0.532
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Full agonist-bound mu-type opioid receptor-G protein complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8k9k
Q-score: 0.543
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- Soluble cytochrome b562,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Full agonist-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide binding protein, beta polypeptide 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
- Damgo (513 Da, Protein from synthetic construct)
Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8k9l
Q-score: 0.505
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- (2~{s})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine (448 Da, Ligand)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- Soluble cytochrome b562,mu-type opioid receptor,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from synthetic construct)