Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8twe
Q-score: 0.592
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8twi
Q-score: 0.499
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the PP2A:B55-FAM122A complex
Resolution: 2.79961 Å
EM Method: Single-particle
Fitted PDBs: 8so0
Q-score: 0.561
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the PP2A:B55-ARPP19 complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8ttb
Q-score: 0.564
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Camp-regulated phosphoprotein 19 (12 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to thiophosphorylated arpp19 (165 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7soy
Q-score: 0.319
Li Y, Balakrishnan VK, Rowse M, Wu CG, Bravos AP, Yadav VK, Ivarsson Y, Strack S, Novikova IV, Xing Y
eLife (2022) 11 [ Pubmed: 35924897 DOI: doi:10.7554/eLife.79736 ]
- The structure of pp2a-b56gamma holoenzyme-pme-1 complex (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Isoform gamma-1 of serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (52 kDa, Protein from Homo sapiens)
- Protein phosphatase methylesterase 1 (42 kDa, Protein from Homo sapiens)