Cryo-EM structure of human SV2A
To Be Published
- Synaptic vesicle glycoprotein 2a (84 kDa, Protein from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (Complex from Homo sapiens)
Cryo-EM structure of human SV2A in complex with Brivaracetam
To Be Published
Structure of synaptic vesicle protein 2A in complex with a nanobody
Mittal A, Martin MF, Levin EJ, Adams C, Yang M, Provins L, Hall A, Procter M, Ledecq M, Hillisch A, Wolff C, Gillard M, Horanyi PS, Coleman JA
Nat Struct Mol Biol (2024) [ Pubmed: 38898101 DOI: doi:10.1038/s41594-024-01335-1 ]
- 1,2-didecanoyl-sn-glycero-3-[phospho-l-serine] (566 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (4r)-1-{[(4s)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one (444 Da, Ligand)
- Nanobody (15 kDa, Protein from Lama glama)
- Synaptic vesicle glycoprotein 2a (75 kDa, Protein from Homo sapiens)
- Protein with a nanobody (98 MDa, Complex from Homo sapiens)
Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody
Mittal A, Martin MF, Levin EJ, Adams C, Yang M, Provins L, Hall A, Procter M, Ledecq M, Hillisch A, Wolff C, Gillard M, Horanyi PS, Coleman JA
Nat Struct Mol Biol (2024) [ Pubmed: 38898101 DOI: doi:10.1038/s41594-024-01335-1 ]
- Luminal domain with nanobody (27 MDa, Complex from Lama glama)
- Nanobody (15 kDa, Protein from Lama glama)
- Synaptic vesicle glycoprotein 2a (75 kDa, Protein from Homo sapiens)
Cryo-EM map of SV2A in complex with brivaracetam and BoNT/A2 Hc
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Botulinum neurotoxin a2 (Protein from Clostridium botulinum)
- Synaptic vesicle glycroprotein 2a in complex with brivaracetam and botulinum neurotoxin a2 hc domain (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (Protein from Homo sapiens)
- Botulinum neurotoxin a2 (Complex)
- Synaptic vesicle glycoprotein 2a (Complex from Clostridium botulinum)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8jlc
Q-score: 0.454
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8jle
Q-score: 0.517
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Synaptic vesicle glycoprotein 2a (12 kDa, Protein from Homo sapiens)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jlf
Q-score: 0.48
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Sv2a in complex with bont/a2 hc domain (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jlg
Q-score: 0.551
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Sv2a ld4 in complex with bont/a2 hc domain from the sv2a-bont/a2 hc complex (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jlh
Q-score: 0.49
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sv2a dimer in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)