Electron Microscopy Data Bank

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Human TRiC-PhLP2A complex in the closed state

Release date: Jan. 31, 2024
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8i1u
Q-score: 0.506

Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH

Nat Commun (2024) 15 pp. 1007-1007 [ DOI: doi:10.1038/s41467-024-45242-x Pubmed: 38307855 ]

Sample:

Human tric/cct complex (Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Aluminum fluoride (83 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
Complex of tric/cct-phlp2a treated with atp-alfx (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Phlp2a (pdcl3) (Complex)
Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-35284

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Human TRiC-PhLP2A complex in the open state

Release date: Jan. 17, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i9u
Q-score: 0.286

Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH

Nat Commun (2024) 15 pp. 1007-1007 [ DOI: doi:10.1038/s41467-024-45242-x Pubmed: 38307855 ]

Sample:

Human tric/cct complex (Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
Complex of human tric/cct and phlp2a (1 MDa, Complex)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
Phlp2a (pdcl3) in human tric/cct complex (Complex from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-35335

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Human TRiC-PhLP2A-actin complex in the closed state

Release date: Dec. 20, 2023
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 8ib8
Q-score: 0.271

Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH

Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]

Sample:

Human tric/cct complex (Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
Human actin (Complex from Homo sapiens)
Complex of tric/cct, phlp2a, and actin treated with atp-alfx (1 MDa, Complex)
T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
Phlp2a (pdcl3) (Complex from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Actb protein (fragment) (41 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-34852

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Human TRiC open state

Release date: Dec. 13, 2023
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hki
Q-score: 0.366

Cong Y, Liu CX

To Be Published

Sample:

T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
Cryo-em structure of human tric at open state (Complex from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-40464

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CCT G beta 5 complex intermediate state

Release date: Nov. 1, 2023
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8sgq
Q-score: 0.248

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ Pubmed: 37852256 DOI: doi:10.1016/j.molcel.2023.09.032 ]

Sample:

T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (55 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (54 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta, n-terminally processed (56 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 in intermediate state (947 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)

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EMD-40486

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CCT-G beta 5 complex closed state 7

Release date: Nov. 1, 2023
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8shf
Q-score: 0.537

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ DOI: doi:10.1016/j.molcel.2023.09.032 Pubmed: 37852256 ]

Sample:

T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta, n-terminally processed (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Aluminum fluoride (83 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
Guanine nucleotide-binding protein subunit beta-5 (43 kDa, Protein from Homo sapiens)
Water (18 Da, Ligand)
Phosducin-like protein (34 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (57 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 in closed state 7 (Complex from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)

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EMD-40439

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Open state CCT-G beta 5 complex

Release date: Oct. 25, 2023
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8sfe
Q-score: 0.3

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ Pubmed: 37852256 DOI: doi:10.1016/j.molcel.2023.09.032 ]

Sample:

T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (55 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (57 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 in open state (947 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit theta (58 kDa, Protein from Homo sapiens)

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EMD-40440

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CCT G beta 5 complex closed state 0

Release date: Oct. 25, 2023
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8sff
Q-score: 0.543

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ DOI: doi:10.1016/j.molcel.2023.09.032 Pubmed: 37852256 ]

Sample:

T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta, n-terminally processed (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 complex in closed state 0 (Complex from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
Aluminum fluoride (83 Da, Ligand)
Water (18 Da, Ligand)
Phosducin-like protein (34 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)

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EMD-40452

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CCT G beta 5 complex closed state 1

Release date: Oct. 25, 2023
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8sg8
Q-score: 0.543

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ Pubmed: 37852256 DOI: doi:10.1016/j.molcel.2023.09.032 ]

Sample:

T-complex protein 1 subunit zeta (57 kDa, Protein from Homo sapiens)
Guanine nucleotide-binding protein subunit beta-5 (43 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
Water (18 Da, Ligand)
T-complex protein 1 subunit eta, n-terminally processed (57 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 in intermediate state (947 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)
Phosducin-like protein (34 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (58 kDa, Protein from Homo sapiens)

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EMD-40453

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CCT G beta 5 complex closed state 3

Release date: Oct. 25, 2023
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8sg9
Q-score: 0.548

Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS

Mol Cell (2023) 83 pp. 3852-3868.e6 [ Pubmed: 37852256 DOI: doi:10.1016/j.molcel.2023.09.032 ]

Sample:

T-complex protein 1 subunit zeta (57 kDa, Protein from Homo sapiens)
Cct-gb5-phlp1 in closed state 3 (Complex from Homo sapiens)
Guanine nucleotide-binding protein subunit beta-5 (43 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
Water (18 Da, Ligand)
T-complex protein 1 subunit eta, n-terminally processed (57 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit delta (56 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (58 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (58 kDa, Protein from Homo sapiens)

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