Cryo-EM Structure of HPIV3 prefusion F trimer in complex with 3x1 Fab
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8dg8
Q-score: 0.39
Caban M, Rodarte JV, Bibby M, Gray MD, Taylor JJ, Pancera M, Boonyaratanakornkit J
Nat Commun (2023) 14 pp. 798-798 [ Pubmed: 36781872 DOI: doi:10.1038/s41467-023-36459-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3x1 monoclonal antibody, vh region (13 kDa, Protein from Homo sapiens)
- Complex of one 3x1 fab bound to the hpiv3 pref trimer (339 kDa, Complex from Homo sapiens)
- 3x1 monoclonal antibody, vl region (11 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (54 kDa, Protein from Human parainfluenza 3 virus (strain NIH 47885))
Cryo-EM Structure of RSV prefusion F trimer in complex with three MxR Fabs
Resolution: 2.24 Å
EM Method: Single-particle
Fitted PDBs: 8dg9
Q-score: 0.676
Caban M, Rodarte JV, Bibby M, Gray MD, Taylor JJ, Pancera M, Boonyaratanakornkit J
Nat Commun (2023) 14 pp. 798-798 [ Pubmed: 36781872 DOI: doi:10.1038/s41467-023-36459-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mab mxr light chain, vl region (11 kDa, Protein from Homo sapiens)
- Trimeric complex of three mxr fabs bound to rsv pref protomer (339 kDa, Complex from Homo sapiens)
- Mab mxr heavy chain, vh region (12 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (63 kDa, Protein from Respiratory syncytial virus A2)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uz4
Q-score: 0.368
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ DOI: doi:10.1016/j.immuni.2022.10.019 Pubmed: 36370711 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s 6p in complex with m8a-3 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab vh and vl domains (Complex from Mus musculus)
- M8a-3 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-3 fab light chain (23 kDa, Protein from Mus musculus)
- M8a-3 fab heavy chain (25 kDa, Protein from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-6
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uz5
Q-score: 0.355
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ DOI: doi:10.1016/j.immuni.2022.10.019 Pubmed: 36370711 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-6 fab heavy chain (25 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- M8a-6 fab vh and vl domains (Complex from Mus musculus)
- Sars-cov-2 s 6p in complex with m8a-6 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-6 fab light chain (23 kDa, Protein from Mus musculus)
- M8a-6 fab ch1 and cl domains (Complex from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uz6
Q-score: 0.477
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s 6p in complex with m8a-28 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-28 fab heavy chain (25 kDa, Protein from Mus musculus)
- M8a-28 fab light chain (23 kDa, Protein from Mus musculus)
- M8a-28 fab vh and vl domains (Complex from Mus musculus)
- M8a-28 fab ch1 and cl domains (Complex from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7uz7
Q-score: 0.36
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ DOI: doi:10.1016/j.immuni.2022.10.019 Pubmed: 36370711 ]
- Sars-cov-2 s 6p in complex with m8a-31 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-31 fab light chain (24 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- M8a-31 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-31 fab vh and vl domains (Complex from Mus musculus)
- M8a-31 fab heavy chain (24 kDa, Protein from Mus musculus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uz8
Q-score: 0.35
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 omicron spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-31 fab vh and vl domains (Complex from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.1 s 6p in complex with m8a-31 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-31 fab light chain (24 kDa, Protein from Mus musculus)
- M8a-31 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-31 fab heavy chain (24 kDa, Protein from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7uz9
Q-score: 0.289
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ DOI: doi:10.1016/j.immuni.2022.10.019 Pubmed: 36370711 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- M8a-34 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-34 fab light chain (23 kDa, Protein from Mus musculus)
- Sars-cov-2 s 6p in complex with m8a-34 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-34 fab vh and vl domains (Complex from Mus musculus)
- M8a-34 fab heavy chain (25 kDa, Protein from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, HSW-1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uza
Q-score: 0.377
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- Hsw-1 fab vh and vl domains (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Hsw-1 fab heavy chain (25 kDa, Protein from Mus musculus)
- Hsw-1 fab light chain (23 kDa, Protein from Mus musculus)
- Sars-cov-2 s 6p in complex with hsw-1 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Hsw-1 fab ch1 and cl domains (Complex from Mus musculus)
Structure of the SARS-CoV-2 S S1 doamin in complex with the mouse antibody Fab fragment, HSW-2
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7uzb
Q-score: 0.334
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ DOI: doi:10.1016/j.immuni.2022.10.019 Pubmed: 36370711 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hsw-2 fab heavy chain (24 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Hsw-2 fab vh and vl domains (Complex from Mus musculus)
- Sars-cov-2 s 6p in complex with hsw-2 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Hsw-2 fab ch1 and cl domains (Complex from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein s1 domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Hsw-2 fab light chain (23 kDa, Protein from Mus musculus)