Terminating ribosome with SRI-41315
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8scb
Q-score: 0.589
Coelho JPL, Yip MCJ, Oltion K, Taunton J, Shao S
To Be Published
- Es12 (14 kDa, Protein from Oryctolagus cuniculus)
- Us12 (15 kDa, Protein from Oryctolagus cuniculus)
- El32 (15 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
- Es6 (28 kDa, Protein from Oryctolagus cuniculus)
- Us4 (22 kDa, Protein from Oryctolagus cuniculus)
- Es30 (14 kDa, Protein from Oryctolagus cuniculus)
- Us7 (22 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- Ribosomal protein l18 (21 kDa, Protein from Oryctolagus cuniculus)
- Us17 (18 kDa, Protein from Oryctolagus cuniculus)
- El28 (15 kDa, Protein from Oryctolagus cuniculus)
- Iron/sulfur cluster (351 Da, Ligand)
- Ul24 (17 kDa, Protein from Oryctolagus cuniculus)
- El39 (6 kDa, Protein from Oryctolagus cuniculus)
- El31 (14 kDa, Protein from Oryctolagus cuniculus)
- Es19 (16 kDa, Protein from Oryctolagus cuniculus)
- El42 (12 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s3 (26 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
- El43 (10 kDa, Protein from Oryctolagus cuniculus)
- Us2 (sa) (32 kDa, Protein from Oryctolagus cuniculus)
- Ubiquitin a-52 residue ribosomal protein fusion product 1 (10 kDa, Protein from Oryctolagus cuniculus)
- E_trna (24 kDa, RNA from Oryctolagus cuniculus)
- 5.8s_rrna (50 kDa, RNA from Oryctolagus cuniculus)
- El22 (14 kDa, Protein from Oryctolagus cuniculus)
- Es21 (9 kDa, Protein from Oryctolagus cuniculus)
- Us8 (14 kDa, Protein from Oryctolagus cuniculus)
- Us5 (31 kDa, Protein from Oryctolagus cuniculus)
- Es27 (9 kDa, Protein from Oryctolagus cuniculus)
- Us11 (18 kDa, Protein from Oryctolagus cuniculus)
- El23 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Terminating rabbit ribosome (4 MDa, Complex from Oryctolagus cuniculus)
- P_trna (24 kDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l7a (36 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- El20 (20 kDa, Protein from Oryctolagus cuniculus)
- Es17 (15 kDa, Protein from Oryctolagus cuniculus)
- Mrna (63 kDa, RNA from Homo sapiens)
- Ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Us14 (6 kDa, Protein from Oryctolagus cuniculus)
- Es8 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
- 28s_rrna (1 MDa, RNA from Oryctolagus cuniculus)
- Eukaryotic peptide chain release factor subunit 1 (51 kDa, Protein from Homo sapiens)
- Es25 (13 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- Ul13 (23 kDa, Protein from Oryctolagus cuniculus)
- Us9 (16 kDa, Protein from Oryctolagus cuniculus)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s26 (13 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- El13 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- Es28 (7 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- 5s_rrna (38 kDa, RNA from Oryctolagus cuniculus)
- Es4 (s4 x isoform) (29 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- El35 (14 kDa, Protein from Oryctolagus cuniculus)
- Es31 (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- El41 (3 kDa, Protein from Oryctolagus cuniculus)
- Es7 (22 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Us10 (13 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l8 (28 kDa, Protein from Oryctolagus cuniculus)
- Es1 (30 kDa, Protein from Oryctolagus cuniculus)
- Atp binding cassette subfamily e member 1 (67 kDa, Protein from Oryctolagus cuniculus)
- El30 (12 kDa, Protein from Oryctolagus cuniculus)
- Nc (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Us13 (17 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- Us19 (17 kDa, Protein from Oryctolagus cuniculus)
- El21 (18 kDa, Protein from Oryctolagus cuniculus)
- 18s_rrna (603 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
- Ul22 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l7 (29 kDa, Protein from Oryctolagus cuniculus)
- El33 (12 kDa, Protein from Oryctolagus cuniculus)
- Us15 (17 kDa, Protein from Oryctolagus cuniculus)
- S10_plectin domain-containing protein (18 kDa, Protein from Oryctolagus cuniculus)
- (2s,4as)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3h,4ah)-dione (359 Da, Ligand)
Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7syo
Q-score: 0.312
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
EMBO J (2022) 41 pp. e110581-e110581 [ DOI: doi:10.15252/embj.2022110581 Pubmed: 35822879 ]
- Us15 (17 kDa, Protein from rabbit)
- Es12 (14 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es1 (30 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Us7 (22 kDa, Protein from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Es21 (9 kDa, Protein from rabbit)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- 18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
- Es6 (28 kDa, Protein from rabbit)
- Us12 (15 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Es24 (15 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex)
- Us4 (22 kDa, Protein from rabbit)
- Es19 (16 kDa, Protein from rabbit)
- 40s ribosomal protein s2 (24 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Us11 (18 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7syp
Q-score: 0.351
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
EMBO J (2022) 41 pp. e110581-e110581 [ DOI: doi:10.15252/embj.2022110581 Pubmed: 35822879 ]
- Us15 (17 kDa, Protein from rabbit)
- Es12 (14 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es1 (30 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- Us7 (22 kDa, Protein from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Es21 (9 kDa, Protein from rabbit)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- 18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
- Es6 (28 kDa, Protein from rabbit)
- Us12 (15 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Hcv ires partially loaded mrna portion (3 kDa, RNA from Hepatitis C virus (isolate 1))
- Us5 (24 kDa, Protein from Oryctolagus cuniculus)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Es24 (15 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex)
- Us4 (22 kDa, Protein from rabbit)
- Es19 (16 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Us11 (18 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
Structure of the wt IRES and 40S ribosome ternary complex, open conformation. Structure 11(wt)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7syq
Q-score: 0.396
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
EMBO J (2022) 41 pp. e110581-e110581 [ DOI: doi:10.15252/embj.2022110581 Pubmed: 35822879 ]
- Us15 (17 kDa, Protein from rabbit)
- Es12 (14 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es1 (30 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- Us7 (22 kDa, Protein from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Us5 (24 kDa, Protein from rabbit)
- Es21 (9 kDa, Protein from rabbit)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- Es6 (28 kDa, Protein from rabbit)
- Us12 (15 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Es24 (15 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex)
- Us4 (22 kDa, Protein from rabbit)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from rabbit)
- Es19 (16 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Us11 (18 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7syr
Q-score: 0.347
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
EMBO J (2022) 41 pp. e110581-e110581 [ DOI: doi:10.15252/embj.2022110581 Pubmed: 35822879 ]
- Us15 (17 kDa, Protein from rabbit)
- Es12 (14 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es1 (30 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- Us7 (22 kDa, Protein from rabbit)
- Met-trna-i-met (24 kDa, RNA from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Us5 (24 kDa, Protein from rabbit)
- Es21 (9 kDa, Protein from rabbit)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- Es6 (28 kDa, Protein from rabbit)
- Us12 (15 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Es24 (15 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex)
- Us4 (22 kDa, Protein from rabbit)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from rabbit)
- Es19 (16 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Us11 (18 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sys
Q-score: 0.469
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
EMBO J (2022) 41 pp. e110581-e110581 [ DOI: doi:10.15252/embj.2022110581 Pubmed: 35822879 ]
- Us12 (15 kDa, Protein from rabbit)
- Us15 (17 kDa, Protein from rabbit)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Us7 (22 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex)
- Es21 (9 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- 18s rrna (603 kDa, RNA from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Es12 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- Es1 (30 kDa, Protein from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Es19 (16 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Us11 (18 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Es24 (15 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Us5 (24 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Es6 (28 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Us4 (22 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- Met-trna-i-met (24 kDa, RNA from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)
Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7syn
Q-score: 0.395
Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
To Be Published
- Us12 (15 kDa, Protein from rabbit)
- Us15 (17 kDa, Protein from rabbit)
- Hcv ires (128 kDa, RNA from Hepatitis C virus (isolate 1))
- Us7 (22 kDa, Protein from rabbit)
- Es7 (47 kDa, Protein from rabbit)
- Es21 (9 kDa, Protein from rabbit)
- Es8 (24 kDa, Protein from rabbit)
- 40s ribosomal protein s2 (24 kDa, Protein from rabbit)
- El41 (3 kDa, Protein from rabbit)
- Us19 (17 kDa, Protein from rabbit)
- 18s rrna (603 kDa, RNA from rabbit)
- Receptor for activated c kinase 1 (rack1) (35 kDa, Protein from rabbit)
- 40s ribosomal small subunit with hcv ires (2 MDa, Complex from Oryctolagus cuniculus)
- Es4 (s4 x isoform) (29 kDa, Protein from rabbit)
- Us13 (17 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- Es12 (14 kDa, Protein from rabbit)
- Us10 (13 kDa, Protein from rabbit)
- Es1 (30 kDa, Protein from rabbit)
- Us8 (14 kDa, Protein from rabbit)
- Us14 (6 kDa, Protein from rabbit)
- Es19 (16 kDa, Protein from rabbit)
- Es26 (11 kDa, Protein from rabbit)
- Us11 (18 kDa, Protein from rabbit)
- Us9 (19 kDa, Protein from rabbit)
- Us17 (18 kDa, Protein from rabbit)
- Es31 (21 kDa, Protein from rabbit)
- Es24 (15 kDa, Protein from rabbit)
- Es28 (7 kDa, Protein from rabbit)
- Es10 (17 kDa, Protein from rabbit)
- Us3 (31 kDa, Protein from rabbit)
- Es30 (14 kDa, Protein from rabbit)
- Es25 (13 kDa, Protein from rabbit)
- Es6 (28 kDa, Protein from rabbit)
- Es27 (9 kDa, Protein from rabbit)
- Us4 (22 kDa, Protein from rabbit)
- Es17 (15 kDa, Protein from rabbit)
- Us2 (sa) (32 kDa, Protein from rabbit)