Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8dn2
Q-score: 0.417
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexane (86 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state 2(expanded-open state) (240 kDa, Complex from Homo sapiens)
- Undecane (156 Da, Ligand)
- N-octane (114 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- N-butane (58 Da, Ligand)
- Glycine (75 Da, Ligand)
- Nonane (128 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8dn3
Q-score: 0.482
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Heptane (100 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- Undecane (156 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Nonane (128 Da, Ligand)
- N-butane (58 Da, Ligand)
- Decane (142 Da, Ligand)
- Heteromeric glycine receptor alpha-1 and beta, apo state (240 kDa, Complex from Homo sapiens)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8dn5
Q-score: 0.462
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexane (86 Da, Ligand)
- Decane (142 Da, Ligand)
- Heptane (100 Da, Ligand)
- Undecane (156 Da, Ligand)
- N-butane (58 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Glycine (75 Da, Ligand)
- Nonane (128 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state1 (open state) (240 kDa, Complex from Homo sapiens)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8f2s
Q-score: 0.548
Goswami U, Rahman MM, Teng J, Hibbs RE
Nat Commun (2023) 14 pp. 3169-3169 [ DOI: doi:10.1038/s41467-023-38827-5 Pubmed: 37264005 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- Cryo-em structure of torpedo nicotinic acetylcholine receptor in complex with rocuronium, desensitized-like state (Complex from Tetronarce californica)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
- Rocuronium (529 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit alpha (49 kDa, Protein from Pacific electric ray)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8f6y
Q-score: 0.54
Goswami U, Rahman MM, Teng J, Hibbs RE
Nat Commun (2023) 14 pp. 3169-3169 [ DOI: doi:10.1038/s41467-023-38827-5 Pubmed: 37264005 ]
- Acetylcholine receptor subunit delta (57 kDa, Protein from Tetronarce californica)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetylcholine receptor subunit alpha (49 kDa, Protein from Tetronarce californica)
- Cryo-em structure of torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state (Complex from Tetronarce californica)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Choline ion (104 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Tetronarce californica)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Tetronarce californica)
- Etomidate (244 Da, Ligand)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8f6z
Q-score: 0.557
Goswami U, Rahman MM, Teng J, Hibbs RE
Nat Commun (2023) 14 pp. 3169-3169 [ DOI: doi:10.1038/s41467-023-38827-5 Pubmed: 37264005 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(n,n,n-trimethylethanaminium) (290 Da, Ligand)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- Cryo-em structure of torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state (Complex from Tetronarce californica)
- Water (18 Da, Ligand)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit alpha (49 kDa, Protein from Pacific electric ray)
Cryo-EM structure of Torpedo acetylcholine receptor in apo form
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7smm
Q-score: 0.622
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Nat Struct Mol Biol (2022) 29 pp. 386-394 [ DOI: doi:10.1038/s41594-022-00737-3 Pubmed: 35301478 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray, Torpedo californica)
- Torpedo acetylcholine receptor in apo form (Complex from Tetronarce californica)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit alpha (50 kDa, Protein from Pacific electric ray)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- Nonane (128 Da, Ligand)
Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7smq
Q-score: 0.583
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Nat Struct Mol Biol (2022) 29 pp. 386-394 [ Pubmed: 35301478 DOI: doi:10.1038/s41594-022-00737-3 ]
- Acetylcholine receptor subunit alpha (50 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray, Torpedo californica)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- Torpedo acetylcholine receptor in apo form plus cholesterol (Complex from Tetronarce californica)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7smr
Q-score: 0.597
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Nat Struct Mol Biol (2022) 29 pp. 386-394 [ Pubmed: 35301478 DOI: doi:10.1038/s41594-022-00737-3 ]
- Acetylcholine receptor subunit alpha (50 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray, Torpedo californica)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- 2-[(aminocarbonyl)oxy]-n,n,n-trimethylethanaminium (147 Da, Ligand)
- Torpedo acetylcholine receptor in complex with carbachol, desensitized state (Complex from Tetronarce californica)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine and carbachol
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 7smt
Q-score: 0.604
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Nat Struct Mol Biol (2022) 29 pp. 386-394 [ Pubmed: 35301478 DOI: doi:10.1038/s41594-022-00737-3 ]
- Acetylcholine receptor subunit alpha (50 kDa, Protein from Pacific electric ray)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Pacific electric ray, Torpedo californica)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Pacific electric ray)
- 2-[(aminocarbonyl)oxy]-n,n,n-trimethylethanaminium (147 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Nonane (128 Da, Ligand)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Pacific electric ray)
- Torpedo acetylcholine receptor in complex with d-tubocurarine and carbachol (Complex from Tetronarce californica)
- D-tubocurarine (610 Da, Ligand)