Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8pqw
Q-score: 0.342
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ DOI: doi:10.1126/science.adk8544 Pubmed: 38547289 ]
- Cytoplasmic dynein-1 bound to dynactin p150 and lis1 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower
Resolution: 9.4 Å
EM Method: Single-particle
Fitted PDBs: 8pr0
Q-score: 0.169
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
Cytoplasmic dynein-B heavy chain bound to IC-LC tower
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 8pr1
Q-score: 0.193
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8pr2
Q-score: 0.418
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- C-jun-amino-terminal kinase-interacting protein 3 (65 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8pr3
Q-score: 0.381
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ DOI: doi:10.1126/science.adk8544 Pubmed: 38547289 ]
- C-jun-amino-terminal kinase-interacting protein 3 (65 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
Human cytoplasmic dynein-1 bound to dynactin and an N-terminal construct of BICD2
Resolution: 8.7 Å
EM Method: Single-particle
Fitted PDBs: 5nw4
Q-score: 0.113
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
Cell (2017) 169 pp. 1303-1314.e18 [ Pubmed: 28602352 DOI: doi:10.1016/j.cell.2017.05.025 ]
- Dynein heavy chain (75 kDa, Protein from Homo sapiens)
- Dynactin 6 (20 kDa, Protein from Pig)
- Dynein intermediate chain (29 kDa, Protein from Homo sapiens)
- Dynactin (Complex from Sus scrofa)
- Dynactin (7 kDa, Protein from Pig)
- Arp11 (46 kDa, Protein from Pig)
- Dynactin (2 kDa, Protein from Pig)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Pig)
- Robl (10 kDa, Protein from Homo sapiens)
- Dynein heavy chain (78 kDa, Protein from Homo sapiens)
- Dynactin shoulder complex (14 kDa, Protein from Pig)
- Arp1 (42 kDa, Protein from Pig)
- Dynein intermediate chain (29 kDa, Protein from Homo sapiens)
- P150 (4 kDa, Protein from Pig)
- Bicd2n (23 kDa, Protein from Homo sapiens)
- Dynein-1 (Complex from Homo sapiens)
- Dynactin (3 kDa, Protein from Pig)
- Dynactin shoulder complex (48 kDa, Protein from Pig)
- Dynactin subunit 5 (24 kDa, Protein from Pig)
- Dynein n-terminal dimerization domain (10 kDa, Protein from Homo sapiens)
- Dynactin shoulder complex (51 kDa, Protein from Pig)
- Dynein n-terminal dimerization domain (10 kDa, Protein from Homo sapiens)
- Dynactin pointed end p62 (20 kDa, Protein from Pig)
- Human cytoplasmic dynein-1 bound to dynactin and an n-terminal construct of bicd2 (2 MDa, Complex)
- Dynactin shoulder complex (11 kDa, Protein from Pig)
- Bicd2 (Complex from Homo sapiens)
- Beta-actin (43 kDa, Protein from Pig)
- Dynein light intermediate chain (25 kDa, Protein from Homo sapiens)
- Dynein light intermediate chain (25 kDa, Protein from Homo sapiens)
- F-actin capping protein beta subunit variant ii (33 kDa, Protein from Pig)
- Dynactin p150 (4 kDa, Protein from Pig)
- Dynactin (5 kDa, Protein from Pig)
Negative stain reconstruction of bovine dynactin complex
Chowdhury S, Ketcham SA, Schroer TA, Lander GC
Nat Struct Mol Biol (2015) 22 pp. 345-347 [ DOI: doi:10.1038/nsmb.2996 Pubmed: 25751425 ]
- Bovine dynactin complex (1 MDa, Sample)
- P150glued (150 kDa, Protein from Bos taurus)
- Actin (42 kDa, Protein from Bos taurus)
- P62 (62 kDa, Protein from Bos taurus)
- Arp1 (42 kDa, Protein from Bos taurus)
- P24 (24 kDa, Protein from Bos taurus)
- Arp11 (42 kDa, Protein from Bos taurus)
- Capz alpha (33 kDa, Protein from Bos taurus)
- P27 (27 kDa, Protein from Bos taurus)
- Capz beta (33 kDa, Protein from Bos taurus)
- P25 (25 kDa, Protein from Bos taurus)
- P50 (50 kDa, Protein from Bos taurus)
Three-dimensional structure of the autophagic phosphatidylinositol 3-kinase complex.
Baskaran S, Carlson L-A, Stjepanovic G, Young LN, Kim DJ, Grob P, Stanley RE, Nogales E, Hurley JH
eLife (2014) 3 [ DOI: doi:10.7554/eLife.05115 Pubmed: 25490155 ]
- Phosphatidylinositol 3-kinase, catalytic subunit type 3 (102 kDa, Protein from Homo sapiens)
- Beclin1 (52 kDa, Protein from Homo sapiens)
- Autophagic phosphatidylinositol 3-kinase complex, pi3kc3-c1. (361 kDa, Sample)
- Autophagy related 14 (55 kDa, Protein from Homo sapiens)
- Phosphoinositide-3-kinase, regulatory subunit 4 (153 kDa, Protein from Homo sapiens)
Dynactin 3D structure: Implications for assembly and dynein binding
Imai H, Narita A, Maeda Y, Schroer TA
J Mol Biol (2014) 426 pp. 3262-3271 [ Pubmed: 25046383 DOI: doi:10.1016/j.jmb.2014.07.010 ]
- Arp1 (Protein from Gallus gallus)
- Arp11 (Protein from Gallus gallus)
- P150glued (Protein from Gallus gallus)
- P50/dynamitin (Protein from Gallus gallus)
- P24 (Protein from Gallus gallus)
- The dynactin complex (Sample)
- Actin (Protein from Gallus gallus)
- P25 (Protein from Gallus gallus)
- P27 (Protein from Gallus gallus)
- P62 (Protein from Gallus gallus)
Cryo-EM map of CAP-Gly-microtubule complex
Wang Q, Crevenna AH, Kunze I, Mizuno N
PNAS (2014) 111 pp. 11347-11352 [ Pubmed: 25059720 DOI: doi:10.1073/pnas.1403135111 ]