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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"~{N}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide" AND film_detector_model:"GATAN K3 BIOQUANTUM (6K X 4K)" AND author_name:"Locher KP"

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EMD-12765

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Encequidar-bound human P-glycoprotein in complex with UIC2-Fab

Release date: Jan. 12, 2022
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7o9w
Q-score: 0.321

Urgaonkar S, Nosol K, Said AM, Nasief NN, Bu Y, Locher KP, Lau JYN, Smolinski MP

J Med Chem (2022) 65 pp. 191-216 [ DOI: doi:10.1021/acs.jmedchem.1c01272 Pubmed: 34928144 ]

Sample:

Multidrug resistance protein 1 (141 kDa, Protein from Homo sapiens)
Uic2 fab-fragment heavy chain (24 kDa, Protein from Mus musculus)
~{n}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{h}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide (690 Da, Ligand)
Fab (Complex from Mus musculus)
Multidrug resistance protein 1 (Complex from Homo sapiens)
Uic2 fab-fragment light chain (24 kDa, Protein from Mus musculus)
Nanodisc reconstituted human p-glycoprotein in complex with uic2-fab and encequidar (240 kDa, Complex)

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