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Project: PRJNA714734

Folic acid supplementation (8 mg/kg diet) promotes colon tumor formation in mice with established colitis induced by carcinogen azoxymethane (AOM) and dextran sulfate sodium sulfate (DSS). This induction of colon tumors was associated with hypomethylation of DNA cased by folic acid supplementation. Overall design: Mice were fed a diet containing folic acid 2 mg/kg chow (basal level), followed by carcinogen azoxymethane injection. Colitis was induced in all mice using 4 cycles of DSS. Immediately after the first DSS treatment, mice were randomized to receive folic acid 0 mg/kg chow (folic acid deficient), 2 mg/kg chow (folic acid basal level) or 8 mg/kg chow (folic acid supplemented) for 16 weeks. At the end of study, mice were euthanized and colons were collected and process for gene expression analyses.

Organism:

Mus musculus (house mouse)

Secondary Study Accession:

SRP310787

Study Title:

Effects of dietary folic acid on methylation status of colon non-neoplastic epithelium and dysplasia in mice with colitis

Center Name:

Research Labs, Coriell Institute for Medical Research

Study Name:

Effects of dietary folic acid on methylation status of colon non-neoplastic epithelium and dysplasia in mice with colitis

ENA-REFSEQ:

PROJECT-ID:

714734

ENA-FIRST-PUBLIC:

2023-09-09

ENA-LAST-UPDATE:

2025-03-05

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Study Accession	Sample Accession	Experiment Accession	Run Accession	Tax Id	Scientific Name	Download All Generated FASTQ files: FTP	Download All Submitted files: FTP	Download All SRA files: FTP	Download All Bam files: FTP
PRJNA714734	SAMN18316696	SRX10350688	SRR13972971	10090	Mus musculus	SRR13972971_1.fastq.gz SRR13972971_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13972971.lite	N/A
PRJNA714734	SAMN18316693	SRX10350691	SRR13972977	10090	Mus musculus	SRR13972977_1.fastq.gz SRR13972977_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13972977.lite	N/A
PRJNA714734	SAMN18316691	SRX10350693	SRR13972983	10090	Mus musculus	SRR13972983_1.fastq.gz SRR13972983_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13972983.lite	N/A
PRJNA714734	SAMN18316690	SRX10350694	SRR13972984	10090	Mus musculus	SRR13972984_1.fastq.gz SRR13972984_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13972984.lite	N/A
PRJNA714734	SAMN18316685	SRX10350699	SRR13972996	10090	Mus musculus	SRR13972996_1.fastq.gz SRR13972996_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13972996.lite	N/A
PRJNA714734	SAMN18316683	SRX10350701	SRR13973001	10090	Mus musculus	SRR13973001_1.fastq.gz SRR13973001_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13973001.lite	N/A
PRJNA714734	SAMN18316682	SRX10350702	SRR13973002	10090	Mus musculus	SRR13973002_1.fastq.gz SRR13973002_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13973002.lite	N/A
PRJNA714734	SAMN18316680	SRX10350704	SRR13973007	10090	Mus musculus	SRR13973007_1.fastq.gz SRR13973007_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13973007.lite	N/A
PRJNA714734	SAMN18316679	SRX10350705	SRR13973008	10090	Mus musculus	SRR13973008_1.fastq.gz SRR13973008_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13973008.lite	N/A
PRJNA714734	SAMN18316679	SRX10350705	SRR13973009	10090	Mus musculus	SRR13973009_1.fastq.gz SRR13973009_2.fastq.gz	N/ASubmitted files are only available for data submitted via ENA	SRR13973009.lite	N/A

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