GWAS Catalog

Gene: ALAS1

Gene information

Gene name

ALAS1

Description

5'-aminolevulinate synthase 1

Location

3:52198086-52214327

Cytogenetic region

Biotype

protein_coding

Available data:

Associations 9

Show entries

Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs164640-T	4 x 10^-10	-	0.529722021411205	-	0.0076479972 unit decrease	[0.0052-0.01]	ALAS1	Life satisfaction	wellbeing measurement	-	GCST007337	3:52213298
rs164640-T	2 x 10^-10	-	0.529722021411205	-	0.0072011882 unit decrease	[0.005-0.0094]	ALAS1	Positive affect	wellbeing measurement	-	GCST007338	3:52213298
rs352169-?	3 x 10^-42	-	NR	-	0.0921271 increase	[0.079-0.105]	ALAS1	EPHB6/VWC2 protein level ratio	EPHB6/VWC2 protein level ratio in blood	-	GCST90314683	3:52202746
rs164640-C	2 x 10^-9	-	NR	-	0.013 unit increase	[0.0091-0.0169]	ALAS1	Bipolar disorder or Crohn's disease (MTAG)	bipolar disorder, Crohn's disease	-	GCST90454588	3:52213298
rs164640-T	1 x 10^-10	-	0.529722021411205	-	0.0059197964 unit decrease	[0.0041-0.0077]	ALAS1	Well-being spectrum (multivariate analysis)	wellbeing measurement	-	GCST007341	3:52213298

Showing 1 to 5 of 9 entries

Studies9

Show entries

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

Suhre K	GCST90314683	2024-02-20	Cell Genom	Genetic associations with ratios between protein…	EPHB6/VWC2 protein level ratio	EPHB6/VWC2 protein level ratio in blood	-	• 43509 European		2	FTP Download
Wang BR	GCST90454588	2023-12-26	J Affect Disord	Genetic correlation, shared loci, but no…	Bipolar disorder or Crohn's disease (MTAG)	bipolar disorder, Crohn's disease	-	• 453732 European		23	Not available
Richardson TG	GCST90092810	2022-02-25	PLoS Biol	Characterising metabolomic signatures of…	Ratio of apolipoprotein B to apolipoprotein A1 levels	apolipoprotein A 1 measurement, apolipoprotein B measurement	-	• 115082 European		78	FTP Download
Baselmans BML	GCST007337	2019-01-14	Nat Genet	Multivariate genome-wide analyses of the…	Life satisfaction	wellbeing measurement	-	• 80852 European		148	FTP Download
Baselmans BML	GCST007338	2019-01-14	Nat Genet	Multivariate genome-wide analyses of the…	Positive affect	wellbeing measurement	-	• 410603 European		191	FTP Download

Showing 1 to 5 of 9 entries