GWAS Catalog

Gene: APOA5

Gene information

Gene name

APOA5

Description

apolipoprotein A5

Location

11:116789367-116792420

Cytogenetic region

Biotype

protein_coding

Available data:

Associations 957

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Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs651821-?	7 x 10^-116	-	NR	-	-	-	APOA5	Metabolic syndrome	metabolic syndrome	-	GCST90444489	11:116791863
rs2075291-A	1 x 10^-29	-	0.06	-	0.3 unit decrease	[0.24-0.36]	APOA5	HDL cholesterol levels	HDL cholesterol change measurement	-	GCST009918	11:116790676
rs651821-C	2 x 10^-12	-	0.348059	-	0.030155 SD units increase	[0.022-0.039]	APOA5	Mean corpuscular hemoglobin concentration	mean corpuscular hemoglobin concentration	-	GCST90002329	11:116791863
rs3135506-C	2 x 10^-15	-	0.062721	-	0.029643 SD unit decrease	[0.022-0.037]	APOA5	Mean corpuscular volume	erythrocyte volume	-	GCST90002334	11:116791691
rs651821-?	3 x 10^-11	-	NR	-	0.02925 unit decrease	[0.021-0.038]	APOA5	Mean corpuscular hemoglobin concentration	mean corpuscular hemoglobin concentration	-	GCST005992	11:116791863

Showing 1 to 5 of 957 entries

Studies423

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First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

Zhu Y	GCST004242	2017-03-30	J Cell Mol Med	Susceptibility loci for metabolic syndrome and…	HDL cholesterol	high density lipoprotein cholesterol measurement	-	• 1742 East Asian	• 10978 East Asian	1	Not available
Lee G	GCST90244795	2022-11-23	Lipids Health Dis	Sex-related differences in single nucleotide…	Dyslipidemia	Rare dyslipidemia	-	• 34199 East Asian	• 6385 East Asian	1	Not available
Riveros-Mckay F	GCST90179202	2020-03-09	PLoS Genet	The influence of rare variants in circulating…	Triglycerides to total lipids ratio in very small VLDL	triglycerides:total lipids ratio, blood VLDL cholesterol amount	-	• 7142 European		1	Not available
Cadby G	GCST90024012	2022-06-06	Nat Commun	Comprehensive genetic analysis of the human…	Cholesteryl ester (22:0) levels	cholesteryl ester 22:0 measurement	-	• 4492 European		1	FTP Download
Surapaneni A	GCST90236673	2022-07-21	Kidney Int	Identification of 969 protein quantitative trait…	Reticulon-1 level in Chronic kidney disease with hypertension and no diabetes (24651_1)	level of reticulon-1 in blood serum	chronic kidney disease, hypertension	• 466 African American or Afro-Caribbean		1	FTP Download

Showing 1 to 5 of 423 entries

Traits145

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Trait label(s)	Reported trait(s)	Association count with APOA5

triglyceride measurement	Triglyceride levels, Triglyceride levels in HIV infection, Triglycerides, Lipid traits, Total triglycerides levels, Triacylglycerol_46:4_[M+NH4]1+ levels, Triacylglycerol_52:3_[M+NH4]1+ levels, Triacylglycerol_52:4_[M+NH4]1+ levels, Triacylglycerol_53:3_[M+NH4]1+ levels, Triacylglycerol_51:3_[M+NH4]1+ levels, Triacylglycerol_52:2_[M+NH4]1+ levels, Triacylglycerol(56:4)_[M+NH4]1+ levels, Triacylglycerol(54:4)_[M+NH4]1+ levels, Triacylglycerol(54:5)_[M+NH4]1+ levels, Triacylglycerol(54:3)_[M+NH4]1+ levels, Triacylglycerol(48:3)_[M+NH4]1+ levels, Triacylglycerol(50:2)_[M+NH4]1+ levels, Triacylglycerol(52:3)_[M+NH4]1+ levels, Triacylglycerol(52:4)_[M+NH4]1+ levels, Triacylglycerol(52:5)_[M+NH4]1+ levels, Triacylglycerol(53:2)_[M+NH4]1+ levels, Triacylglycerol(53:4)_[M+NH4]1+ levels, Triacylglycerol(54:2)_[M+NH4]1+ levels, Triacylglycerol(53:3)_[M+NH4]1+ levels, Triacylglycerol(52:2)_[M+NH4]1+ levels, Triacylglycerol(52:1)_[M+NH4]1+ levels, Triacylglycerol(50:3)_[M+NH4]1+ levels, Triacylglycerol(50:4)_[M+NH4]1+ levels, Triacylglycerol(51:4)_[M+NH4]1+ levels, Triacylglycerol(51:2)_[M+NH4]1+ levels, Triacylglycerol(51:3)_[M+NH4]1+ levels, Triacylglyceride levels, Triglyceride levels in pregnancy, Triglyceride levels (MTAG)	163
sphingomyelin measurement	Sphingomyelin(32:1)_[M+H]1+ levels, Sphingomyelin_42:2_[M+H]1+ levels, Sphingomyelin(42:4)_[M+H]1+ levels, Sphingomyelin_34:1_[M+H]1+ levels, Sphingomyelin_36:1_[M+H]1+ levels, Sphingomyelin(34:0)_[M+H]1+ levels, Sphingomyelin(34:1)_[M-CH3]1- levels, Sphingomyelin(34:0)_[M-CH3]1- levels, Sphingomyelin(34:1)_[M+H]1+ levels, Sphingomyelin_32:1_[M+H]1+ levels, Sphingomyelin_34:0_[M+H]1+ levels, Sphingomyelin(38:0)_[M+H]1+ levels, Sphingomyelin(38:1)_[M+H]1+ levels, Sphingomyelin(37:1)_[M+H]1+ levels, Sphingomyelin(36:1)_[M-CH3]1- levels, Sphingomyelin(36:1)_[M+H]1+ levels, Sphingomyelin(34:2)_[M+H]1+ levels, Sphingomyelin(36:2)_[M+H]1+ levels, Sphingomyelin(36:0)_[M+H]1+ levels, Sphingomyelin(36:0)_[M-CH3]1- levels, Sphingomyelin(42:3)_[M+H]1+ levels, Sphingomyelin(41:2)_[M+H]1+ levels, Sphingomyelin(42:2)_[M+OAc]1- levels, Sphingomyelin(40:2)_[M-CH3]1- levels, Sphingomyelin(41:1)_[M+H]1+ levels, Sphingomyelin_36:0_[M+H]1+ levels, Sphingomyelin_39:1_[M+H]1+ levels, Sphingomyelin_38:1_[M+H]1+ levels, Sphingomyelin(39:1)_[M+H]1+ levels, Sphingomyelin_40:2_[M+H]1+ levels, Sphingomyelin_40:1_[M+H]1+ levels	141
serum metabolite measurement	Serum metabolite levels (CMS), Serum metabolite levels	102
high density lipoprotein cholesterol measurement	High density lipoprotein cholesterol levels, Low HDL-cholesterol levels, HDL cholesterol levels, HDL cholesterol, Concentration of large HDL particles, Low high density lipoprotein cholesterol levels, High-density lipoprotein levels, High-density lipoprotein levels (MTAG), Concentration of very large HDL particles	62
phosphatidylcholine measurement	Phosphatidylcholine-2O_32:0_[M+H]1+ levels, Phosphatidylcholine-O_36:4_[M+H]1+/Phosphatidylcholine-P_36:3_[M+H]1+ levels, Phosphatidylcholine-O_36:2_[M+H]1+/Phosphatidylcholine-P_36:1_[M+H]1+/Phosphatidylethanolamine-P_39:1_[M+H]1+ levels, Phosphatidylcholine-O(39:1)_[M+H]1+/Phosphatidylethanolamine-P(39:0)_[M+H]1+ levels, Phosphatidylcholine-O_34:2_[M+H]1+/Phosphatidylcholine-P_34:1_[M+H]1+/Phosphatidylethanolamine-O_37:2_[M+H]1+ levels, Phosphatidylcholine-O_34:3_[M+H]1+/Phosphatidylcholine-P_34:2_[M+H]1+/Phosphatidylethanolamine-P_37:2_[M+H]1+ levels, Phosphatidylcholine-O_34:1_[M+H]1+/Phosphatidylcholine-P_34:0_[M+H]1+/Phosphatidylethanolamine-O_37:1_[M+H]1+ levels, Phosphatidylcholine-O_32:1_[M+H]1+/Phosphatidylcholine-P_32:0_[M+H]1+/Phosphatidylethanolamine-O_35:1_[M+H]1+ levels, Phosphatidylcholine-O_31:0_[M+H]1+/Phosphatidylethanolamine-O_34:0_[M+H]1+ levels, Phosphatidylcholine-O(32:0)_[M+H]1+/Phosphatidylethanolamine-O(35:0)_[M+H]1+ levels, Phosphatidylcholine-O(34:1)_[M+H]1+/Phosphatidylcholine-P(34:0)_[M+H]1+/Phosphatidylethanolamine-O(37:1)_[M+H]1+ levels, Phosphatidylcholine-O(36:5)_[M+H]1+/Phosphatidylcholine-P(36:4)_[M+H]1+ levels, Phosphatidylcholine(32:0)_[M+H]1+/Phosphatidylethanolamine(35:0)_[M+H]1+/Phosphatidate(37:1)_[M+NH4]1+ levels, Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels, Phosphatidylcholine(45:0)_[M-H]1- levels	41

Showing 1 to 5 of 145 entries