GWAS Catalog

Gene: APOL1

Gene information

Gene name

APOL1

Description

apolipoprotein L1

Location

22:36253071-36267530

Cytogenetic region

Biotype

protein_coding

Available data:

Associations 84

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Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs136161-G	2 x 10^-6	(recessive )	NR	1.27	-	[1.10-1.46]	APOL1	Diabetic kidney disease	diabetic nephropathy	-	GCST003098	22:36261386
rs136161-G	5 x 10^-7	(AA, recessive )	0.74	1.36	-	[1.21-1.54]	APOL1	Diabetic kidney disease	diabetic nephropathy	-	GCST003098	22:36261386
rs2239785-G	5 x 10^-13	(AA)	0.64	-	-	-	APOL1	Glomerulosclerosis	focal segmental glomerulosclerosis	-	GCST000741	22:36265284
rs10854688-C	2 x 10^-21	-	0.310558	-	0.2486 unit decrease	[0.2-0.3]	APOL1	Apolipoprotein L1 (analyte X11510.31) levels	protein measurement	-	GCST90421521	22:36257808
rs10854688-C	7 x 10^-34	-	0.312235	-	0.3229 unit decrease	[0.27-0.37]	APOL1	Apolipoprotein L1 (analyte X11510.51) levels	protein measurement	-	GCST90421522	22:36257808

Showing 1 to 5 of 84 entries

Studies79

Show entries

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

Genovese G	GCST000741	2010-07-28	Kidney Int	A risk allele for focal segmental…	Glomerulosclerosis	focal segmental glomerulosclerosis	-	• 1815 African American or Afro-Caribbean • 1592 European	• 299 European	1	Not available
Western D	GCST90421521	2024-11-11	Nat Genet	Proteogenomic analysis of human cerebrospinal…	Apolipoprotein L1 (analyte X11510.31) levels	protein measurement	-	• 3506 European		1	FTP Download
Western D	GCST90421522	2024-11-11	Nat Genet	Proteogenomic analysis of human cerebrospinal…	Apolipoprotein L1 (analyte X11510.51) levels	protein measurement	-	• 3334 European		1	FTP Download
Surapaneni A	GCST90233274	2022-07-21	Kidney Int	Identification of 969 protein quantitative trait…	Apolipoprotein L1 level in Chronic kidney disease with hypertension and no diabetes (11510_51)	apolipoprotein L1 measurement	chronic kidney disease, hypertension	• 466 African American or Afro-Caribbean		1	FTP Download
Sun BB	GCST90240649	2018-06-06	Nature	Genomic atlas of the human plasma proteome.	CDGSH iron-sulfur domain-containing protein 1 levels (CISD1.7745.3.3)	CDGSH iron-sulfur domain-containing protein 1 measurement	-	• 3301 European		1	FTP Download

Showing 1 to 5 of 79 entries