GWAS Catalog

Gene: KMT2A

Gene information

Gene name

KMT2A

Description

lysine methyltransferase 2A

Location

11:118436456-118526832

Cytogenetic region

Biotype

protein_coding

Available data:

Associations 29

Show entries

Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs7948661-C	5 x 10^-6	(5 degree of freedom test)	NR	1.05	-	[1.00-1.10]	KMT2A	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)	attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder	-	GCST001877	11:118470934
rs9332817-?	4 x 10^-13	-	NR	-	0.0244415 unit increase	[0.016-0.032]	KMT2A	Metabolic syndrome	metabolic syndrome	-	GCST90444487	11:118494495
rs7948661-?	4 x 10^-8	-	NR	-	-	-	KMT2A	Depressive symptoms (MTAG)	depressive symptom measurement	-	GCST010642	11:118470934
rs2017122-T	1 x 10^-6	-	NR	-	4.811745 z score increase	[NR]	KMT2A	Depression	depressive symptom measurement, major depressive disorder	-	GCST003769	11:118444134
rs9332817-C	4 x 10^-8	-	0.0265006	-	0.115795 unit decrease	[0.075-0.157]	KMT2A	Metabolic syndrome	metabolic syndrome	-	GCST009602	11:118494495

Showing 1 to 5 of 29 entries

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Studies29

Show entries

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

Okbay A	GCST003769	2016-04-18	Nat Genet	Genetic variants associated with subjective…	Depression	depressive symptom measurement, major depressive disorder	-	• 180866 European	• 368890 European	15	FTP Download or API access
A Gadd D	GCST90102615	2021-11-10	Wellcome Open Res	The genetic and epigenetic profile of serum…	S100 calcium-binding protein levels	S100 calcium-binding protein B measurement	-	• 769 European		22	FTP Download
Smoller JW	GCST001877	2013-02-27	Lancet	Identification of risk loci with shared effects…	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)	attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder	-	• 61220 European		74	Not available
Wu Y	GCST010642	2020-06-30	Transl Psychiatry	Multi-trait analysis for genome-wide association…	Depressive symptoms (MTAG)	depressive symptom measurement	-	• 955012 NR		63	Not available
Scammell BH	GCST90272876	2023-06-29	Hum Mol Genet	Multi-ancestry genome-wide analysis identifies…	Sleep duration	sleep duration trait	-	• 7288 African unspecified • 7485 South Asian • 8726 Hispanic or Latin American • 446118 European • 13618 East Asian		73	Not available

Showing 1 to 5 of 29 entries

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