GWAS Catalog

Location

2:164656581

Cytogenetic region

Most severe consequence

Intergenic variant

Mapped gene(s)

Alleles

T/C(forward strand)

Minor allele

MAF

0.395997

GWAS Catalog data is currently mapped to Genome Assembly GRCh38.p14 and dbSNP Build156

Available data:

Show entries

Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs10195252-T	5 x 10^-30	(EA, women)	0.5905	-	0.0519 unit increase	[0.043-0.061]	COBLL1	Waist-to-hip ratio adjusted for body mass index	BMI-adjusted waist-hip ratio	-	GCST002782	2:164656581
rs10195252-T	6 x 10^-15	(EA)	0.5926	-	0.027 unit increase	[0.02-0.034]	COBLL1	Waist-to-hip ratio adjusted for body mass index	BMI-adjusted waist-hip ratio	-	GCST002782	2:164656581
rs10195252-T	2 x 10^-31	(women)	0.5807	-	0.0524 unit increase	[0.044-0.061]	COBLL1	Waist-to-hip ratio adjusted for body mass index	BMI-adjusted waist-hip ratio	-	GCST002782	2:164656581
rs10195252-T	4 x 10^-16	-	0.5838	-	0.0274 unit increase	[0.021-0.034]	COBLL1	Waist-to-hip ratio adjusted for body mass index	BMI-adjusted waist-hip ratio	-	GCST002782	2:164656581
rs10195252-T	4 x 10^-30	-	0.590334060130194	-	-	-	COBLL1	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	-	GCST005962	2:164656581

Showing 1 to 5 of 96 entries

Show entries

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

Wojcik GL	GCST008033	2019-06-19	Nature	Genetic analyses of diverse populations improves…	Fasting blood insulin	blood insulin amount	-	• 12687 Hispanic or Latin American • 1397 Oceanian • 395 Native American • 5525 African American or Afro-Caribbean • 1547 East Asian, Asian unspecified		6	FTP Download or API access
Lagou V	GCST012074	2021-01-05	Nat Commun	Sex-dimorphic genetic effects and novel loci for…	Fasting insulin	blood insulin amount	-	• 50404 European		7	Not available
Graff M	GCST004577	2017-04-27	PLoS Genet	Genome-wide physical activity interactions in…	Waist-to-hip ratio adjusted for BMI in inactive individuals	BMI-adjusted waist-hip ratio	physical activity measurement	• 31133 European • 5379 South Asian • 352 East Asian • 812 African American or Afro-Caribbean	• 10600 European • 1501 African American or Afro-Caribbean	7	Not available
Verma A	GCST90479886	2024-07-19	Science	Diversity and scale: Genetic architecture of…	Insulin pump user (PheCode 250.3)	insulin measurement	-	• 118639 African American or Afro-Caribbean • 442188 European • 58470 Hispanic or Latin American		10	FTP Download
Heid IM	GCST000829	2010-10-10	Nat Genet	Meta-analysis identifies 13 new loci associated…	Waist-hip ratio	waist-hip ratio	-	• 77167 European	• 113636 European	16	Not available

Showing 1 to 5 of 79 entries

Trait label(s)	Reported trait(s)	Association count with rs10195252

BMI-adjusted waist-hip ratio	Waist-to-hip ratio adjusted for body mass index, Waist-to-hip ratio adjusted for BMI, Waist-to-hip ratio adjusted for BMI in active individuals, Waist-to-hip ratio adjusted for BMI in inactive individuals, Waist-to-hip ratio adjusted for BMI in non-smokers	14
BMI-adjusted waist-hip ratio, physical activity measurement	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction), Waist-to-hip ratio adjusted for body mass index	8
triglyceride measurement	Triglycerides, Serum total triglyceride levels, triglyceride (maximum, inv-norm transformed), triglyceride (minimum, inv-norm transformed), triglyceride (mean, inv-norm transformed)	7
waist-hip ratio	Waist-hip ratio	6
HbA1c measurement	Hemoglobin A1c (HbA1c, mean, inv-norm transformed), Hemoglobin A1c (HbA1c, minimum, inv-norm transformed), Hemoglobin A1c (HbA1c, maximum, inv-norm transformed)	5

Variant: rs10195252