GWAS Catalog

Variant information

Location

11:61781402

Cytogenetic region

11q12.2

Most severe consequence

Intron variant

Mapped gene(s)

MYRF, TMEM258

Alleles

G/A(forward strand)

Minor allele

MAF

0.100863

GWAS Catalog data is currently mapped to Genome Assembly GRCh38.p14 and dbSNP Build156

Available data:

Associations 53

Show entries

Variant and risk allele	P-value	P-value annotation	RAF	OR	Beta	CI	Mapped gene	Reported trait	Trait(s)	Background trait(s)	Study accession	Location

rs174532-A	1 x 10^-8	-	0.1	-	0.267 unit increase	[0.18-0.36]	TMEM258, MYRF	Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome	omega-3 polyunsaturated fatty acid measurement	metabolic syndrome	GCST010318	11:61781402
rs174532-A	1 x 10^-12	-	NR	-	0.0723753 unit decrease	[0.052-0.092]	TMEM258, MYRF	Phosphatidylcholine_36:2_[M+OAc]1-/Phosphatidylserine_40:1_[M-H]1- levels	phosphatidylcholine measurement	-	GCST90060465	11:61781402
rs174532-A	7 x 10^-27	-	NR	-	0.165781 unit decrease	[0.14-0.2]	TMEM258, MYRF	Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels	phosphatidylcholine measurement	-	GCST90060349	11:61781402
rs174532-A	3 x 10^-14	-	NR	-	0.117495 unit increase	[0.087-0.148]	TMEM258, MYRF	Phosphatidylcholine_40:4_[M+H]1+/Phosphatidylethanolamine_43:4_[M+H]1+ levels	phosphatidylcholine measurement	-	GCST90060457	11:61781402
rs174532-A	3 x 10^-19	-	NR	-	0.144224 unit increase	[0.11-0.18]	TMEM258, MYRF	Phosphatidylcholine_40:5_[M+H]1+ levels	phosphatidylcholine measurement	-	GCST90060451	11:61781402

Showing 1 to 5 of 53 entries

Studies53

Show entries

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Replication sample number	Association count	Summary statistics

First author	Study accession	Pub. date	Journal	Title	Reported trait	Trait(s)	Background trait(s)	Discovery sample number	Association count	Summary statistics

Tabassum R	GCST90244237	2022-10-04	J Am Heart Assoc	Lipidome- and Genome-Wide Study to Understand…	Phosphatidylcholine (16:0_20:1) levels	level of Phosphatidylcholine (16:0_20:1) in blood serum	-	• 2624 European	2	Not available
Cadby G	GCST90024182	2022-06-06	Nat Commun	Comprehensive genetic analysis of the human…	Lysophosphatidylcholine (22:5) [sn1] (n6) levels	lysophosphatidylcholine 22:5 measurement	-	• 4492 European	6	FTP Download
Coltell O	GCST010318	2020-01-24	Nutrients	Genome-Wide Association Study for Serum Omega-3…	Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome	omega-3 polyunsaturated fatty acid measurement	metabolic syndrome	• 426 European	10	Not available
Harshfield EL	GCST90060375	2021-09-10	BMC Med	Genome-wide analysis of blood lipid metabolites…	Phosphatidylcholine-O_38:5_[M+H]1+/Phosphatidylcholine-P_38:4_[M+H]1+ levels	phosphatidylcholine measurement	-	• 13814 European	28	FTP Download
Harshfield EL	GCST90060559	2021-09-10	BMC Med	Genome-wide analysis of blood lipid metabolites…	Triacylglycerol_58:10_[M+NH4]1+ levels	triglyceride measurement	-	• 13814 European	27	FTP Download

Showing 1 to 5 of 53 entries

Traits18

Show entries

Trait label(s)	Reported trait(s)	Association count with rs174532

phosphatidylcholine measurement	Phosphatidylcholine_36:2_[M+OAc]1-/Phosphatidylserine_40:1_[M-H]1- levels, Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels, Phosphatidylcholine_40:4_[M+H]1+/Phosphatidylethanolamine_43:4_[M+H]1+ levels, Phosphatidylcholine_40:5_[M+H]1+ levels, Phosphatidylcholine_40:7_[M+H]1+ levels, Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels, Phosphatidylcholine-O_36:4_[M+H]1+/Phosphatidylcholine-P_36:3_[M+H]1+ levels, Phosphatidylcholine-O_38:5_[M+H]1+/Phosphatidylcholine-P_38:4_[M+H]1+ levels, Phosphatidylcholine_37:5_[M+H]1+/Phosphatidylethanolamine_40:5_[M+H]1+/Phosphatidate_42:6_[M+NH4]1+ levels, Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels, Phosphatidylcholine_38:3_[M+H]1+/Phosphatidylethanolamine_41:3_[M+H]1+/Phosphatidate_43:4_[M+NH4]1+ levels, Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels, Phosphatidylcholine_32:2_[M+H]1+/Phosphatidylethanolamine_35:2_[M+H]1+/Phosphatidate_37:3_[M+NH4]1+ levels, Phosphatidylcholine_34:3_[M+H]1+/Phosphatidylethanolamine_37:3_[M+H]1+/Phosphatidate_39:4_[M+NH4]1+ levels, Phosphatidylcholine_35:2_[M+H]1+/Phosphatidylethanolamine_38:2_[M+H]1+/Phosphatidate_40:3_[M+NH4]1+ levels, Phosphatidylcholine_34:2_[M+H]1+/Phosphatidylethanolamine_37:2_[M+H]1+/Phosphatidate_39:3_[M+NH4]1+ levels, Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels, Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels, Phosphatidylcholine_34:2_[M+OAc]1-/Phosphatidylserine_38:1_[M-H]1- levels	19
phosphatidylethanolamine measurement	Phosphatidylethanolamine_38:3_[M-H]1- levels, Phosphatidylethanolamine_38:5_[M-H]1- levels, Phosphatidylethanolamine_38:4_[M-H]1- levels, Phosphatidylethanolamine_36:2_[M-H]1- levels, Phosphatidylethanolamine_35:2_[M-H]1- levels, Phosphatidylethanolamine_36:3_[M-H]1- levels, Phosphatidylethanolamine_34:2_[M-H]1- levels, Phosphatidylethanolamine_39:4_[M-H]1- levels, Phosphatidylethanolamine-O_38:5_[M-H]1-/Phosphatidylethanolamine-P_38:4_[M-H]1- levels, Phosphatidylethanolamine-O_40:5_[M-H]1-/Phosphatidylethanolamine-P_40:4_[M-H]1- levels	10
triglyceride measurement	Triacylglycerol_56:6_[M+NH4]1+ levels, Triacylglycerol_58:7_[M+NH4]1+ levels, Triacylglycerol_58:10_[M+NH4]1+ levels, Triacylglycerol_58:9_[M+NH4]1+ levels	4
lysophosphatidylethanolamine measurement	Lysophosphatidylethanolamine_18:2_[M-H]1- levels, Lysophosphatidylethanolamine_20:4_[M-H]1- levels, Lysophosphatidylethanolamine_22:4_[M-H]1- levels	3
phosphatidylinositol measurement	Phosphatidylinositol_34:0_[M+H]1+ levels, Phosphatidylinositol_36:2_[M-H]1- levels, Phosphatidylinositol_36:3_[M-H]1- levels	3

Showing 1 to 5 of 18 entries

Variant: rs174532

Variant information

Associations 53

Studies53

Traits18

Linkage disequilibrium (LD)

Variant source
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Trait category
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Variant: rs174532

Variant information

Associations 53

Studies53

Traits18

Linkage disequilibrium (LD)

Variant sourceFilter plot by selecting/deselecting source

Trait categoryFilter plot by selecting/deselecting trait category

Variant source
Filter plot by selecting/deselecting source

Trait category
Filter plot by selecting/deselecting trait category