Search results < Expression Atlas < EMBL-EBI

ENSG00000196652 (ZKSCAN5)

homo sapiens

zinc finger with KRAB and SCAN domains 5

Baseline expression
Differential expression
ZKSCAN5 information

-1

-2.2

1

2.1

Display log₂-fold change

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Log₂-fold change

Species

Gene name

Comparison

Experimental variables

Experiment name

'non-small cell lung carcinoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'P-bodies (cytosolic RNP granules)' vs 'pre-sorted fraction'

fraction

RNA-Seq of purified P-bodies from HEK293 cells

'colorectal carcinoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'pancreatic adenocarcinoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'tumor' vs 'normal'

clinical information

Transcription profiling by high throughput sequencing in esophageal squamous cell carcinoma cells.

'breast carcinoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'doxorubicin; 5 micomolar and T0901317; 5 micromolar' vs 'none'

compound

LXR mediated-signalling protects human hair follicles against doxorubicin-induced toxicity ex vivo

'hepatobiliary carcinoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'7 hour' vs '0 hour' in 'MDA-LM2'

cell line, time

Transcription profiling by high throughput sequencing in MDA-MB-231 and MDA-LM2 cell lines

'EX00000246; stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '6 hour'

compound, time, treatment

GPBAR1 agonism has a broad impact on blocking macrophage activation

'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '48 hour'

infect, time

Time course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells

'DAOY M14; MYC overexpression' vs 'DAOY; vector control'

cell type, genotype

Bone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma

'6 to 8 weeks post ovulation' vs 'adult' in 'normal'

developmental stage, disease

Comparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma

'ejaculatory azoospermia; Johnsen score count 2' vs 'normal; Johnsen score count 10'

disease, histology

Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '54 hour'

infect, time

Time course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells

'ejaculatory azoospermia; Johnsen score count 3.2' vs 'normal; Johnsen score count 10'

disease, histology

Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

'DAOY M14; MYC overexpression' vs 'DAOY; wild type'

cell type, genotype

Bone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma

'Neisserial ligand MafA' vs 'none'

infect, stimulus

Transcriptome analysis of human brain microvascular endothelial cells response to Neisseria meningitidis and its antigen MafA using RNA-seq

'CD3/CD28 beads' vs 'none' in 'none'

stimulus, xenograft

RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs

'human intestinal organoids derived from H9 stem cells' vs 'Undifferentiated H9 Stem Cells'

cell type

Transcriptional Profiling of human pluripotent stem cells and and derived tissues

'3 to 5 weeks post ovulation' vs 'adult' in 'normal'

developmental stage, disease

Comparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma

'deprived of Methionine' vs 'control media' in 'MCF7' at '24 hour'

cell line, growth condition, time

Transcription profiling by array of human MCF-7 and PC3 cells grown under amino acid deprived or rich conditions for 24 or 48 hours

'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '60 hour'

infect, time

Time course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells

'0 μM Methionine media' vs 'control media' in 'PC3' at '24 hour'

cell line, growth condition, time

Transcription profiling by array of human MCF-7 and PC3 cells grown under amino acid deprived or rich conditions for 24 or 48 hours

'10 unit per milliliter; JFHA' vs 'control'

compound

Primary human hepatocytes treated with IL28B and the HCV JFH1 Genotype 2A clone.

'154; 1 micromolar' vs 'DMSO'

compound

Development of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways

'T-helper 1 polarising' at '5 days' vs 'no stimulus'

cell type, sampling time point, stimulus

Transcription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets

'injected in NSG mouse' vs 'none' in 'none'

stimulus, xenograft

RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs

'injected in NSG-HLA-A2/HHD mouse' vs 'none' in 'none'

stimulus, xenograft

RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs

'doxycycline-mediated expression of dominant-negative FOS' vs 'wild type'

phenotype

Transcription profiling of oesophageal adenocarcinoma by RNA-seq

'7 hour' vs '0 hour' in 'MDA-MB-231'

cell line, time

Transcription profiling by high throughput sequencing in MDA-MB-231 and MDA-LM2 cell lines

'valproic acid; 15 millimolar' vs 'control' at '1 day'

compound, sampling time point

RNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.

'1 μM Methionine media' vs 'control media' in 'PC3' at '24 hour'

cell line, growth condition, time

Transcription profiling by array of human MCF-7 and PC3 cells grown under amino acid deprived or rich conditions for 24 or 48 hours

'cigarette smoke' vs 'vehicle' at '24 hour'

compound, time

Transcription profiling by array of normal human bronchial epithelial cells after exposure to smoke

'atopic eczema; normal skin' vs 'normal; normal skin'

clinical information, disease, phenotype

Transcription profiling by array of acute and chronic atopic dermatitis compared to normal skin

'0 μM Methionine media' vs 'control media' in 'PC3' at '48 hour'

cell line, growth condition, time

Transcription profiling by array of human MCF-7 and PC3 cells grown under amino acid deprived or rich conditions for 24 or 48 hours

'glioblastoma' vs 'normal'

block, disease

RNA-seq of blood platelets from six tumor types and healthy donors

'T-helper 2 polarising' at '5 days' vs 'no stimulus'

cell type, sampling time point, stimulus

Transcription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets

'Digoxin; 400 nanomolar' vs 'DMSO'

compound

Expression profiling of Jurkat cells infected with HIV-1 and treated with digoxin or DMSO

'DMSO' in 'stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '6 hour'

compound, time, treatment

GPBAR1 agonism has a broad impact on blocking macrophage activation

'16 to 24 weeks post ovulation' vs 'adult' in 'normal'

developmental stage, disease

Comparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma

ENSG00000196652

'Growth Medium' vs 'none' in 'normal'

disease, stimulus

A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]

'Cal51; cocultured with fibroblast HFF1' vs 'Cal51; normal'

cell line, growth condition

System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity

'GLV-1h153' at '24 hour' vs 'control'

infect, time

Expression data from human pancreatic cells PANC-1 infected with oncolytic vaccinia virus GLV-1h153

'trichostatin A; 500 nanomolar' vs 'control'

compound

Transcription profiling by high throughput sequencing of human aortic endothelial cell treated with TSA

'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '72 hour'

infect, time

Time course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells

'LBH589 (panobinostat)' vs 'DMSO' in 'MCF7her2'

cell line, compound

Transcription profiling by array of three human cancer cell lines (H295R, HeLa and MCF-7her2) with and without treatment with histone deacetylase inhibitor LBH589 (panobinostat)

'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 8'

disease, histology

Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

'golgicide A' vs 'DMSO' at '20 hour'

compound, time

Microarray analysis of human A549 lung cancer cells treated with brefeldin A, golgicide A, monensin or vehicle control for 8 h or 20 h

'differentiated; hAKPC-P' vs 'undifferentiated; hIPod'

cell type, phenotype

Differentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes

'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 7'

disease, histology

Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

'differentiated; hAKPC-P' vs 're-differentiated; hIPod'

cell type, phenotype

Differentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes

'Zaire ebolavirus lacking the VP30 gene' vs 'mock' at '18 hour'

infect, time

Human U937 cell transcriptome response to Zaire Ebola virus wild-type in the delta-VP30 background and delta-mucin virus

Synonym	ZFP95, ZNF914, ZSCAN37
Ortholog	ZKSCAN5 (Macaca mulatta), ZKSCAN5 (Chlorocebus sabaeus), Zkscan5 (Mus musculus), ZKSCAN5 (Equus caballus), ZKSCAN5 (Pongo abelii), ENSOCUG00000002447 (Oryctolagus cuniculus), ZKSCAN5 (Pan troglodytes), ZKSCAN5 (Dasypus novemcinctus), ZKSCAN5 (Bos taurus), ZKSCAN5 (Sus scrofa), ENSPANG00000000548 (Papio anubis), ENSOARG00020022085 (Sus scrofa), ZKSCAN5 (Gorilla gorilla)
Gene ontology	RNA polymerase II proximal promoter sequence-specific DNA binding, regulation of transcription by RNA polymerase II, zinc ion binding … and 7 more
InterPro	SCAN domain (domain), IPR036051, Krueppel-associated box (domain), IPR038269, Zinc finger C2H2-type (domain), IPR036236
Ensembl gene	ENSG00000196652
Ensembl transcript	ENST00000451158, ENST00000326775, ENST00000454175, ENST00000394170
Ensembl protein	ENSP00000405716, ENSP00000392104, ENSP00000377725, ENSP00000322872
Entrez	23660
UniProt	Q9Y2L8, F8WBD4
Gene biotype	protein_coding
Design element	203731_s_at, 3014892, 3014891, 3014894, 3014893, 3014896, 3014895, 3014898, 3014897, 3014899, 11740186_a_at, 41452_at, 11743419_a_at, 203730_s_at, g11036641_3p_a_at, 11743420_a_at, 3014890, A_23_P259663, 11763363_x_at, ILMN_1775428, 11763438_a_at, 3014861, 3014860, 3014863, 3014862, 3014865, 3014864, 3014900, 11763362_at, 3014866, 3014868, 203731_PM_s_at, 3014872, 3014871, 3014874, 3014873, 3014876, 3014878, 3014877, 3014879, ILMN_1759423, Hs.110839.0.S1_3p_a_at, 17048967, ILMN_1695847, 3014881, 3014880, 3014883, 3014885, 3014884, 3014887, 3014886, 3014889, 3014888, 23660_at, 203730_PM_s_at, 8134621, A_24_P317637
Reactome pathway ID	RNA Polymerase II Transcription, Generic Transcription Pathway, Gene expression (Transcription)