| Name | Inhibitor family I1 (Kazal family) |
|---|
| Family type peptidase | I01.003 - ovomucoid inhibitor unit 3 (Meleagris gallopavo), MEROPS Accession MER0017774 (inhibitor unit: 135-185) |
| Content of family | Inhibitor family I1 contains inhibitors of serine endopeptidases. |
| History |
Identifier created: MEROPS 6.1 (10 January 2003)
Family I1 is frequently referred to as the Kazal family of inhibitors, in reference to the pancreatic secretory trypsin inhibitor (now known as SPINK1, I01.011) that was discovered by Kazal et al. (1948). As a result of the work on the inhibitor units of ovomucoid by Michael Laskowski, Jr. and his colleagues, the mode of interaction of inhibitors in family I1 with peptidases has become the most thoroughly characterised of all such interactions (e.g. Laskowski et al., 2003; see also Laskowski mechanism). |
| Peptidases inhibited | Peptidases inhibited belong to families S1 and S8 (Laskowski & Kato, 1980; Lu et al., 1997). They include endopeptidases with a broad range of specificities. |
| Mechanism of inhibition | Inhibitors in family I1 inhibit serine peptidases by the Laskowski mechanism also termed the 'standard' mechanism (Laskowski & Kato, 1980). |
| Molecular structure | The family contains compound inhibitors; numbers of inhibitor units include 1 (e.g. I01.018), 2 (e.g. LI01-003, LI01-007), 3 (e.g. LI01-001), 4 (e.g. LI01-006), 5, 7 (e.g. LI01-002), 9 and 15 (e.g. LI01-004) (Rawlings et al., 2004). |
| Clan | IA |
| Inhibitors and Homologues |
MEROPS ID |
Structure |
| ovomucoid inhibitor unit 1 | I01.001 | Yes |
| ovomucoid inhibitor unit 2 | I01.002 | Yes |
| ovomucoid inhibitor unit 3 | I01.003 | Yes |
| ovoinhibitor inhibitor unit 1 | I01.004 | - |
| ovoinhibitor inhibitor unit 2 | I01.005 | - |
| ovoinhibitor inhibitor unit 3 | I01.006 | - |
| ovoinhibitor inhibitor unit 4 | I01.007 | - |
| ovoinhibitor inhibitor unit 5 | I01.008 | - |
| ovoinhibitor inhibitor unit 6 | I01.009 | - |
| ovoinhibitor inhibitor unit 7 | I01.010 | - |
| SPINK1 | I01.011 | Yes |
| SPINK2 | I01.012 | Yes |
| SPINK5 inhibitor unit 1 | I01.013 | Yes |
| BUSI-I inhibitor | I01.014 | - |
| SPINK6 | I01.015 | Yes |
| bikazin salivary inhibitor inhibitor unit 1 | I01.016 | - |
| bikazin salivary inhibitor inhibitor unit 2 | I01.017 | - |
| elastase inhibitor (Anemonia sulcata) | I01.018 | Yes |
| rhodniin inhibitor unit 1 | I01.019 | Yes |
| bdellin | I01.020 | - |
| tryptase inhibitor (Hirudo medicinalis) | I01.021 | Yes |
| dipetalogastin inhibitor unit 2 | I01.022 | - |
| dipetalogastin inhibitor unit 3 | I01.023 | Yes |
| TgPI-1 inhibitor inhibitor unit 1 (Toxoplasma gondii) | I01.024 | - |
| TgPI-1 inhibitor inhibitor unit 2 (Toxoplasma gondii) | I01.025 | - |
| TgPI-1 inhibitor inhibitor unit 3 (Toxoplasma gondii) | I01.026 | - |
| TgPI-1 inhibitor inhibitor unit 4 (Toxoplasma gondii) | I01.027 | - |
| SPINK5 inhibitor unit 10 | I01.028 | - |
| SPINK5 inhibitor unit 3 | I01.029 | - |
| SPINK5 inhibitor unit 4 | I01.030 | - |
| rhodniin inhibitor unit 2 | I01.031 | - |
| SPINK5 inhibitor unit 6 | I01.032 | - |
| NcPI-S protein (Neospora caninum) | I01.033 | - |
| EPI1 protein inhibitor domain 1 (Phytophthora infestans) | I01.034 | - |
| skin protein 1 (Phyllomedusa sauvagii) | I01.035 | - |
| dipetalogastin inhibitor unit 1 | I01.036 | - |
| RECK protein inhibitor unit 1 | I01.037 | - |
| infestin 4 (Triatoma infestans) | I01.038 | - |
| PAPI-I inhibitor unit 1 | I01.039 | - |
| EPI1 protein inhibitor domain 2 (Phytophthora infestans) | I01.040 | - |
| inhibitor TgTI (Toxoplasma gondii) | I01.041 | - |
| BmSPI inhibitor (Bombyx mori) | I01.042 | - |
| Kazal inhibitor CCTI (Caiman crocodylus) | I01.043 | - |
| SPINK5 inhibitor unit 15 | I01.044 | - |
| EPI10 (Phythophthora sp.) inhibitor domain 1 | I01.045 | - |
| CmPI-II (Cenchritis muricatus) | I01.046 | - |
| turkinh1 (Meleagris gallopavo) | I01.047 | - |
| CrSPI-1 unit 2 (Carcinoscorpius rotundicauda) | I01.048 | Yes |
| male reproductive tract-specific Kazal-type proteinase inhibitor unit 2 (Macrobrachium rosenbergii) | I01.049 | - |
| five-domain Kazal-type serine proteinase inhibitor (Penaeus monodon) inhibitor unit 2 | I01.050 | - |
| five-domain Kazal-type serine proteinase inhibitor (Penaeus monodon) inhibitor unit 3 | I01.051 | - |
| five-domain Kazal-type serine proteinase inhibitor (Penaeus monodon) inhibitor unit 4 | I01.052 | - |
| five-domain Kazal-type serine proteinase inhibitor (Penaeus monodon) inhibitor unit 5 | I01.053 | - |
| SPINK9 | I01.054 | - |
| EPI10 (Phythophthora infestans) inhibitor domain 2 | I01.055 | - |
| AaTI (Aedes aegypti) | I01.056 | Yes |
| esophagus cancer-related gene-2 | I01.057 | Yes |
| infestin 1R | I01.058 | Yes |
| greglin | I01.059 | Yes |
| SPINK13 | I01.060 | - |
| bdellin-KL (Hirudo nipponia) | I01.062 | - |
| SPINK5 inhibitor unit 2 | I01.950 | Yes |
| SPINK5 inhibitor unit 5 | I01.951 | - |
| SPINK5 inhibitor unit 7 | I01.953 | - |
| SPINK5 inhibitor unit 8 | I01.954 | - |
| SPINK5 inhibitor unit 9 | I01.955 | - |
| SPINK5 inhibitor unit 11 | I01.957 | - |
| SPINK5 inhibitor unit 12 | I01.958 | - |
| SPINK5 inhibitor unit 13 | I01.959 | - |
| SPINK5 inhibitor unit 14 | I01.960 | - |
| dipetalogastin unit 1-2 | I01.962 | Yes |
| PAPI-I protein unit 2 (Pacifastacus leniusculus) | I01.963 | - |
| PAPI-I protein unit 3 (Pacifastacus leniusculus) | I01.964 | - |
| PAPI-I protein unit 4 (Pacifastacus leniusculus) | I01.965 | - |
| follistatin | I01.966 | Yes |
| follistatin-related protein 1 | I01.967 | - |
| follistatin-related protein 3 | I01.968 | Yes |
| tomoregulin | I01.969 | - |
| SPINK4 protein | I01.970 | Yes |
| organic anion transporter polypeptide-related | I01.972 | - |
| LOC153217 protein (Homo sapiens) | I01.973 | - |
| DKFZP761G1118 protein | I01.974 | - |
| LOC225445 protein | I01.975 | - |
| 9230117E20Rik protein (Mus musculus) | I01.976 | - |
| KIAA1263 protein | I01.977 | - |
| Tmeff2 protein | I01.978 | Yes |
| A230091H23 protein (Mus musculus) and similar | I01.979 | - |
| Spock2 protein | I01.980 | - |
| Family I01 non-peptidase homologues | non-peptidase homologue | - |
| Family I01 unassigned peptidases | unassigned | Yes |
