Family I53

Family

Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

Summary for family I53

Name	Inhibitor family I53 (madanin family)
Family type peptidase	I53.001 - madanin 1 (Haemaphysalis longicornis) (Haemaphysalis longicornis), MEROPS Accession MER0029433 (inhibitor unit: 1-79)
Content of family	Inhibitor family I53 contains inhibitors of the serine-type endopeptidase thrombin.
History	Identifier created: MEROPS 8.2 (4 August 2008) Parasitic arthropods that feed on mammalian blood prevent coagulation to prolong feeding. The tick Haemaphysalis longicornis produces inhibitors in its saliva known as madanins which inhibits thrombin (S01.217) (Iwanaga et al., 2003).
Peptidases inhibited	Thrombin.
Mechanism of inhibition	Madanins prevent conversion of fibrinogen to fibrin, the activation of coagulation factors V and VIII and aggregation of platelets, but not the amidolytic action of thrombin. Therefore madanins bind to the thrombin exosite 1 and not to its active site (Iwanaga et al., 2003).
Molecular structure
Clan	unassigned

Distribution of family	Bacteria	-
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	details
	Animals	details
	Viruses	-

Biological functions
Statistics for family I53	Sequences:	6
	Identifiers:	1
	Identifiers with PDB entries:	1
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR021716
	PFAM	PF11714

Inhibitors and Homologues	MEROPS ID	Structure
madanin 1 (Haemaphysalis longicornis)	I53.001	Yes
Family I53 unassigned peptidases	unassigned	-