Family I58
Summary for family I58
Name | Inhibitor family I58 (staphostatin A family) |
Family type peptidase | I58.001 - staphostatin A (Staphylococcus aureus), MEROPS Accession MER0029960 (inhibitor unit: 1-108) |
Content of family | Inhibitor family I58 contains an inhibitor of the cysteine endopeptidase, staphopain A (C47.001). |
History |
Identifier created: MEROPS 6.5 (22 December 2003) Staphostatin A was described by Rzychon et al., 2003. |
Peptidases inhibited | Staphostatin A specifically inhibits staphopain A; no effect on any other peptidase has been detected (Rzychon et al., 2003). |
Mechanism of inhibition | Taken together with the similar protein folds, the conservation of reactive site sequence between staphostatins B and A strongly suggests that the type of interaction revealed by the complex of staphostatin B with staphopain B (Filipek et al., 2003) is a good model for the complex of staphostatin A with staphopain A (Dubin et al., 2003). |
Molecular structure | The protein fold of staphostatin A determined by NMR is described as identical to that of staphostatin B (I57.001) determined crystallographically (Dubin et al., 2003). The staphostatin A molecule contains a single disulfide loop, but elimination of this has no effect on the inhibitory activity (Dubin et al., 2003). The fold of the staphostatins is similar to that of the Erwinia metallopeptidase inhibitor (I38.001), and families I38, I57 and I58 are accordingly grouped together in clan IK. |
Clan | IK |
Distribution of family
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Bacteria |
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Protozoa |
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Plants |
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Viruses |
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