Family I58

Family

Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

Summary for family I58

NameInhibitor family I58 (staphostatin A family)
Family type peptidaseI58.001 - staphostatin A (Staphylococcus aureus), MEROPS Accession MER0029960 (inhibitor unit: 1-108)
Content of familyInhibitor family I58 contains an inhibitor of the cysteine endopeptidase, staphopain A (C47.001).
History Identifier created: MEROPS 6.5 (22 December 2003)
Staphostatin A was described by Rzychon et al., 2003.
Peptidases inhibitedStaphostatin A specifically inhibits staphopain A; no effect on any other peptidase has been detected (Rzychon et al., 2003).
Mechanism of inhibitionTaken together with the similar protein folds, the conservation of reactive site sequence between staphostatins B and A strongly suggests that the type of interaction revealed by the complex of staphostatin B with staphopain B (Filipek et al., 2003) is a good model for the complex of staphostatin A with staphopain A (Dubin et al., 2003).
Molecular structureThe protein fold of staphostatin A determined by NMR is described as identical to that of staphostatin B (I57.001) determined crystallographically (Dubin et al., 2003). The staphostatin A molecule contains a single disulfide loop, but elimination of this has no effect on the inhibitory activity (Dubin et al., 2003). The fold of the staphostatins is similar to that of the Erwinia metallopeptidase inhibitor (I38.001), and families I38, I57 and I58 are accordingly grouped together in clan IK.
ClanIK
Distribution of family Bacteria details  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses -  
Biological functionsThe genes encoding staphostatin A and staphopain A are located in a single operon in Staphylococcus aureus, and in vitro, the two have to be expressed together for efficient expression (Wladyka et al., 2004). It is likely that the biological role of staphostatin A is the regulation of the activity of staphopain A.
Statistics for family I58Sequences:7
Identifiers:1
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Other databases CATH 2.40.310.10
INTERPRO IPR015112
PFAM PF09022
SCOP 101869
Inhibitors and Homologues MEROPS ID Structure
staphostatin AI58.001Yes
Family I58 non-peptidase homologuesnon-peptidase homologue-
Family I58 unassigned peptidasesunassigned-