Family I81
Summary for family I81
Name | Inhibitor family I81 (toxostatin family) |
Family type peptidase | I81.001 - toxostatin-1 (Toxoplasma gondii) (Toxoplasma gondii), MEROPS Accession MER0152588 (inhibitor unit: 81-218) |
Content of family | Family I81 contains inhibitors of cysteine endopeptidases. |
History |
Identifier created: MEROPS 8.4 (6 April 2009) The pathogen Toxoplasma gondii infects numerous vertebrates including man. Toxostatins are endogenous inhibitors in the pathogen which regulate the activity of endogenous cysteine peptidases (Huang et al., 2009). |
Peptidases inhibited | Several cysteine peptidases from family C1 are inhibited, but especially the TgCPL peptidase (C01.149) from Toxoplasma gondii. |
Molecular structure | |
Clan | unassigned |
Distribution of family
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Bacteria |
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Archaea |
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Protozoa |
details |
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Fungi |
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Plants |
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Animals |
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Viruses |
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Biological functions | Although toxostatins reduce cysteine peptidase activity in pathogen lysates, they have no effect on pathogen invasion or intracellular multiplication (Huang et al., 2009). |
Statistics for family I81 | Sequences: | 1 |
| Identifiers: | 1 |
| Identifiers with PDB entries: | 0 |
Downloadable files |
Sequence library (FastA format) |
Inhibitors and Homologues |
MEROPS ID |
Structure |
toxostatin-1 (Toxoplasma gondii) | I81.001 | - |