› 4fdc

X-ray diffraction
2.4Å resolution

Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF)

Released:
DOI: 10.2210/pdb4fdc/pdb
PDB entry 4fdc coloured by chain, front view.
PDB entry 4fdc coloured by chain, side view.
PDB entry 4fdc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
Rinaldi C, Grunseich C, Sevrioukova IF, Schindler A, Horkayne-Szakaly I, Lamperti C, Landouré G, Kennerson ML, Burnett BG, Bönnemann C, Biesecker LG, Ghezzi D, Zeviani M, Fischbeck KH
Am J Hum Genet 91 1095-102 (2012)
PMID: 23217327

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis-inducing factor 1, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 514 amino acids
Theoretical weight: 56.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95831 (Residues: 103-613; Coverage: 83%)
Gene names: AIF, AIFM1, PDCD8
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FAD 1 x FAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 102.4Å b: 62.7Å c: 101.922Å
α: 90° β: 118.57° γ: 90°
R-values:
R R work R free
0.255 0.253 0.297
Expression system: Escherichia coli BL21(DE3)

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Citations

22 review citations

Cell biology. Metabolic control of cell death.
Green et al. (2014)
21 more

2 mentions without citation

Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
Rinaldi et al. (2012)
1 more