EMD-24453

Single-particle
2.9 Å
EMD-24453
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Deposition: 15/07/2021
Map released: 13/04/2022
Last modified: 13/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-24453
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7rgp summary report (pdf.gz) Map and 7rgp FULL report (pdf.gz)
EMICSS annotations (xml)

cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide

EMD-24453

Single-particle
2.9 Å
EMD-24453
3D View Gallery
Deposition: 15/07/2021
Map released: 13/04/2022
Last modified: 13/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Mus musculus, Lama glama
Sample: cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide, trimeric G protein complex and stabilizing antibodies
Fitted models: 7rgp

Deposition Authors: Sun B , Kobilka BK , Sloop KW , Feng D , Kobilka TS
Structural determinants of dual incretin receptor agonism by tirzepatide.
Sun B , Willard FS, Feng D , Alsina-Fernandez J, Chen Q , Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA , Aihara E, Brown RA , Bueno AB , Emmerson PJ, Moyers JS , Kobilka TS, Coghlan MP , Kobilka BK , Sloop KW
(2022) PNAS , 119 , e2116506119 - e2116506119
PUBMED: 35333651
DOI: doi:10.1073/pnas.2116506119
ISSN: 1091-6490
ASTM: PNASA6