EMD-28779
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
EMD-28779
Single-particle3.1 Å
![EMD-28779](https://www.ebi.ac.uk/emdb/images/entry/EMD-28779/400_28779.gif)
Map released: 12/04/2023
Last modified: 12/04/2023
Sample Organism:
Homo sapiens,
Diguetia canities
Sample: VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Fitted models: 8f0s
Deposition Authors: Kschonsak M
,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine D,
McKerall SJ,
Hackos DH,
Deng L,
Chen J,
Sutherlin D,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J
,
Ciferri C
,
Tellis JC
Sample: VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Fitted models: 8f0s
Deposition Authors: Kschonsak M
![](http://www.ebi.ac.uk/web_guidelines/images/logos/orcid/orcid_16x16.png)
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Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Kschonsak M
,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine DF,
McKerrall SJ,
Hackos DH,
Deng L,
Chen J,
Li T,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J
,
Ciferri C
,
Tellis JC
(2023) eLife , 12
![](http://www.ebi.ac.uk/web_guidelines/images/logos/orcid/orcid_16x16.png)
![](http://www.ebi.ac.uk/web_guidelines/images/logos/orcid/orcid_16x16.png)
![](http://www.ebi.ac.uk/web_guidelines/images/logos/orcid/orcid_16x16.png)
![](http://www.ebi.ac.uk/web_guidelines/images/logos/orcid/orcid_16x16.png)
(2023) eLife , 12