EMD-39621

Single-particle
2.68 Å
EMD-39621 Deposition: 29/03/2024
Map released: 18/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-39621

Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex

EMD-39621

Single-particle
2.68 Å
EMD-39621 Deposition: 29/03/2024
Map released: 18/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the human glucagon-like peptide-1 receptor in complex with Retatrutide and G protein
Fitted models: 8yw3

Deposition Authors: Li WZ, Zhou QT, Cong ZT, Yuan QN, Li WX, Zhao FH, Xu HE , Zhao LH , Yang DH, Wang MW , Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y, Wu BL, Yang DH, Zhao LH , Xu HE , Wang MW
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Li W, Zhou Q , Cong Z, Yuan Q, Li W, Zhao F, Xu HE , Zhao LH , Yang D , Wang MW
(2024) Cell Discov , 10 , 77 - 77
PUBMED: 39019866
DOI: doi:10.1038/s41421-024-00700-0
ISSN: 2056-5968