EMD-4632

Single-particle
19.1 Å
EMD-4632
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Deposition: 22/02/2019
Map released: 25/03/2020
Last modified: 25/11/2020
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EMD-4632
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A dimer component of alpha-1 antitrypsin polymers isolated from ZZ explant liver tissue and decorated with Fab 4B12 (component A with ~60 degree rotation around the dimer axis)

EMD-4632

Single-particle
19.1 Å
EMD-4632
3D View Gallery
Deposition: 22/02/2019
Map released: 25/03/2020
Last modified: 25/11/2020
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Polymers of the severe deficiency Z variant of alpha-1 antitrypsin labelled with 4B12 Fab fragments

Deposition Authors: Elliston ELK, Faull SV, Orlova EV, Gooptu B, Lomas DA, Irving JA
The structural basis for Z alpha 1 -antitrypsin polymerization in the liver.
Faull SV , Elliston ELK , Gooptu B , Jagger AM , Aldobiyan I, Redzej A , Badaoui M , Heyer-Chauhan N , Rashid ST , Reynolds GM , Adams DH , Miranda E, Orlova EV , Irving JA , Lomas DA
(2020) Sci Adv , 6
PUBMED: 33087346
DOI: doi:10.1126/sciadv.abc1370
ISSN: 2375-2548