EMD-6400
Electron microscopy of BRCA1(5832insC) mutant-RNAP II transcriptional complex
EMD-6400
Single-particle26.0 Å
![EMD-6400](https://www.ebi.ac.uk/emdb/images/entry/EMD-6400/400_6400.gif)
Map released: 03/08/2016
Last modified: 14/09/2016
Sample Organism:
Homo sapiens
Sample: Mutant BRCA1(5382insC)-RNAP II transcriptional assemblies isolated from hereditary breast cancer cells
Deposition Authors: Winton CE, Gilmore BL, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z, Kelly DF
Sample: Mutant BRCA1(5382insC)-RNAP II transcriptional assemblies isolated from hereditary breast cancer cells
Deposition Authors: Winton CE, Gilmore BL, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z, Kelly DF
A microchip platform for structural oncology applications
Winton CE,
Gilmore BL,
Demmert AC,
Karageorge V,
Sheng Z,
Kelly DF
(2016) NPJ Breast Cancer , 2 , 16016 - 16016
(2016) NPJ Breast Cancer , 2 , 16016 - 16016
Secondary citations:
- Gilmore BL, Winton CE, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z & Kelly DF. (2016) A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease. Sci Rep,
- Walmacq C, Cheung AC, Kireeva ML, Lubkowska L, Ye C, Gotte D, Strathern JN, Carell T, Cramer P & Kashlev M. (2012) Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. Mol. Cell, 46, 18 - 29
- Brzovic PS, Rajagopal P, Hoyt DW, King MC & Klevit RE. (2001) Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat. Struct. Mol. Biol., 8, 833 - 837
- Vijay-Kumar S, Bugg CE & Cook WJ. (1987) Structure of ubiquitin refined at 1.8 A resolution. J. Mol. Biol., 194, 531 - 544
- Williams RS, Green R & Glover JN. (2001) Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat. Struct. Mol. Biol., 8, 838 - 842