Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148765 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transcription factor p65
Molecule details ›
Chains: A, C
Length: 301 amino acids
Theoretical weight: 34.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 301 amino acids
Theoretical weight: 34.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q04206 (Residues: 20-320; Coverage: 55%)
Sequence domains:
Structure domains:
Nuclear factor NF-kappa-B p50 subunit
Molecule details ›
Chains: B, D
Length: 107 amino acids
Theoretical weight: 12.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Rel homology dimerisation domain
Structure domains: Immunoglobulins
Length: 107 amino acids
Theoretical weight: 12.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P19838 (Residues: 248-354; Coverage: 11%)
Sequence domains: Rel homology dimerisation domain
Structure domains: Immunoglobulins
NF-kappa-B inhibitor alpha
Molecule details ›
Chains: E, F
Length: 213 amino acids
Theoretical weight: 23.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain
Length: 213 amino acids
Theoretical weight: 23.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P25963 (Residues: 70-282; Coverage: 67%)
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X25
Spacegroup:
P21
Expression system: Escherichia coli
