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CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11

X-ray diffraction
2Å resolution
PDB entry 1aph coloured by chain, front view.
PDB entry 1aph coloured by chain, side view.
PDB entry 1aph coloured by chain, top view.
Source organism: Bos taurus
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3378.96 Å2
Buried surface area: 1750.34 Å2
Dissociation area: 773.65 Å2
Dissociation energy (ΔGdiss): 10.28 kcal/mol
Dissociation entropy (TΔSdiss): 8.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134251
Assembly 2
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 5270.05 Å2
Buried surface area: 4988.54 Å2
Dissociation area: 1,626.78 Å2
Dissociation energy (ΔGdiss): 19.52 kcal/mol
Dissociation entropy (TΔSdiss): 16.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134254
Assembly 3
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 6090.54 Å2
Buried surface area: 4171.44 Å2
Dissociation area: 342.28 Å2
Dissociation energy (ΔGdiss): -6.72 kcal/mol
Dissociation entropy (TΔSdiss): 9.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134254

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.34 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P01317 (Residues: 85-105; Coverage: 26%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1aph, assembly 1, front view.
Insulin A chain in PDB entry 1aph, assembly 1, side view.
Insulin A chain in PDB entry 1aph, assembly 1, top view.
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Insulin B chain
Chain: B
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P01317 (Residues: 25-54; Coverage: 37%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1aph, assembly 1, front view.
Insulin B chain in PDB entry 1aph, assembly 1, side view.
Insulin B chain in PDB entry 1aph, assembly 1, top view.
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