› › Function and Biology

CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H

Source organism: Escherichia coli
Biochemical function: protein binding
Biological process: pyrimidine nucleotide biosynthetic process
Cellular component: aspartate carbamoyltransferase complex

Quick links

EC 2.1.3.2: Aspartate carbamoyltransferase

Reaction catalysed:
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
Systematic name:
Carbamoyl-phosphate:L-aspartate carbamoyltransferase
Alternative Name(s):
  • ATCase
  • Aspartate carbamyltransferase
  • Aspartate transcarbamoylase
  • Aspartate transcarbamylase
  • Aspartic acid transcarbamoylase
  • Aspartic carbamyltransferase
  • Aspartic transcarbamylase
  • Carbamoylaspartotranskinase
  • Carbamylaspartotranskinase
  • L-aspartate transcarbamoylase
  • L-aspartate transcarbamylase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02748
Domain description: Aspartate carbamoyltransferase regulatory chain, metal binding domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of Pfam domain PF02748 (Aspartate carbamoyltransferase regulatory chain, metal binding domain) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.

PF01948
Domain description: Aspartate carbamoyltransferase regulatory chain, allosteric domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of Pfam domain PF01948 (Aspartate carbamoyltransferase regulatory chain, allosteric domain) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.

PF00185
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
The deposited structure of PDB entry 1at1 contains 2 copies of Pfam domain PF00185 (Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain) in Aspartate carbamoyltransferase catalytic subunit. Showing 1 copy in chain A.

PF02729
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
The deposited structure of PDB entry 1at1 contains 2 copies of Pfam domain PF02729 (Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain) in Aspartate carbamoyltransferase catalytic subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006130
Domain description: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR002801
Domain description: Aspartate transcarbamylase regulatory subunit
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR036901
Domain description: Aspartate/ornithine carbamoyltransferase superfamily
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR036793
Domain description: Aspartate carbamoyltransferase regulatory subunit, N-terminal domain superfamily
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR002082
Domain description: Aspartate carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR020542
Domain description: Aspartate carbamoyltransferase regulatory subunit, C-terminal
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR036792
Domain description: Aspartate carbamoyltransferase regulatory subunit, C-terminal domain superfamily
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR020545
Domain description: Aspartate carbamoyltransferase regulatory subunit, N-terminal
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR006131
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR006132
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit

Structure domains

CATH CATH domains
3.40.50.1370
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
The deposited structure of PDB entry 1at1 contains 4 copies of CATH domain 3.40.50.1370 (Rossmann fold) in Aspartate carbamoyltransferase catalytic subunit. Showing 2 copies in chain A.
2.30.30.20
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of CATH domain 2.30.30.20 (SH3 type barrels.) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.
3.30.70.140
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of CATH domain 3.30.70.140 (Alpha-Beta Plaits) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.
SCOP SCOP annotations
53672
Class: Alpha and beta proteins (a/b)
Fold: ATC-like
Superfamily: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
The deposited structure of PDB entry 1at1 contains 4 copies of SCOP domain 53672 (Aspartate/ornithine carbamoyltransferase) in Aspartate carbamoyltransferase catalytic subunit. Showing 2 copies in chain A.
57826
Class: Small proteins
Fold: Rubredoxin-like
Superfamily: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of SCOP domain 57826 (Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.
54894
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
The deposited structure of PDB entry 1at1 contains 2 copies of SCOP domain 54894 (Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain) in Aspartate carbamoyltransferase regulatory chain. Showing 1 copy in chain B.

Quick links