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NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.

X-ray diffraction
2.1Å resolution
PDB entry 1c3e coloured by chain, front view.
PDB entry 1c3e coloured by chain, side view.
PDB entry 1c3e coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphoribosylglycinamide formyltransferase
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Multimeric state: homo dimer
Accessible surface area: 18825.64 Å2
Buried surface area: 3724.84 Å2
Dissociation area: 257.93 Å2
Dissociation energy (ΔGdiss): -10.65 kcal/mol
Dissociation entropy (TΔSdiss): 12.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139986

Macromolecules

Phosphoribosylglycinamide formyltransferase
Chains: A, B
Length: 209 amino acids
Theoretical weight: 22.95 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P08179 (Residues: 1-209; Coverage: 99%)
Gene names: JW2485, b2500, purN
Pfam: Formyl transferase
InterPro:
CATH: Formyl transferase, N-terminal domain
SCOP: Formyltransferase
Phosphoribosylglycinamide formyltransferase in PDB entry 1c3e, assembly 1, front view.
Phosphoribosylglycinamide formyltransferase in PDB entry 1c3e, assembly 1, side view.
Phosphoribosylglycinamide formyltransferase in PDB entry 1c3e, assembly 1, top view.
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